摘要
目的:探索丹红注射液联合通督调神针法对进展性缺血性脑卒中患者血脂代谢及炎性因子的影响。方法:本研究采用回顾性调查的方式将我院卒中单元于2018年10月以前收治的进展性缺血性脑卒中住院患者57例作为对照组,将2019年1月-2020年1月期间收治的相同住院患者59例设为治疗组。对照组按卒中单元标准进行个体化治疗,包括对症处理、溶栓并静滴奥拉西坦注射液,治疗组在对照组治疗基础上静滴丹红注射液并联合通督调神针法进行鱼刺康复治疗。两组均治疗21 d。采用美国国立卫生研究院卒中量表(National Institute of Health stroke scale,NIHSS)比较两组治疗前、治疗3 d、21 d和90 d随访评分。比较两组治疗后炎性因子、血脂代谢水平及临床疗效。结果:与对照组比较,NIHSS评分表明治疗组治疗21 d和90 d随访低于对照组(P<0.05),且高密度脂蛋白(HDL-C)明显升高,而低密度脂蛋白(LDL-C)、甘油三脂(TG)、总胆固醇(TC)、肿瘤坏死因子α(TNF-α)、C反应蛋白(CRP)、白细胞介素1β(IL-1β)和IL-6均低于对照组(P<0.05),治疗组治疗21 d总有效率(83.05%)明显高于对照组患者(75.43%),两组比较差异具有统计学意义(P<0.05)。结论:丹红注射液联合通督调神针法可抑制进展性缺血性脑卒中炎性反应,改善血脂代谢并促进患者神经功能的恢复。
Objective To explore the effect of Danhong injection combined with Tong Du TiaoShen acupuncture on blood lipid metabolism and inflammatory factors in patients with progressive ischemic stroke.Methods In this study,57 inpatients of progressive ischemic stroke admitted in stroke unit of our hospital before October 2018 were collected as control group by retrospective investigation,and 59 inpatients of the same period from January 2019 to January 2020 were set as treatment group.The control group was treated individually according to the stroke unit standard,including symptomatic treatment,thrombolysis and intravenous drip of oxiracetam injection.The treatment group was treated with intravenous drip of Danhong injection combined with Tongdu Tiaoshen acupuncture on the basis of the control group.The two groups were treated for 21 days.The National Institute of Health Stroke Scale(NIHSS)was used to compare the follow-up scores of the two groups before treatment,3 days,21 days and 90 days after treatment.The levels of inflammatory factors,blood lipid metabolism and clinical effects were compared between the two groups.Results Compared with control group,NIHSS score showed that the treatment group for 21 days and 90 days were lower than the control group(P<0.05),and high density lipoprotein(HDL-C)increased significantly,while the low density lipoprotein(LDL-C),glycerin three greases(TG),total cholesterol(TC),tumor necrosis factor alpha(TNF-alpha),C reactive protein(CRP),interleukin 1 beta(IL-1 beta)and IL-6 were lower than the control group(P<0.05).The total effective rate(83.05%)of the treatment group for 21 days was significantly higher than that of the control group(75.43%),and the difference between the two groups was statistically significant(P<0.05).The treatment group for 21 days,the total efficiency(83.05%)was significantly higher than the control group(75.43%),with significant differences between the two groups(P<0.05).Conclusion Danhong injection combined with Tong Du Tiao Shen acupuncture can inhibit inflamma
作者
廖恒
高玉姣
穆敬平
LIAO Heng;GAO Yu-jiao;MU Jing-ping(Department of sleep disorders,Taihe Hospital,Hubei University of Medicine,Shiyan,Hubei 442000,China;Department of Surgery,Taihe Hospital,Hubei University of Medicine,Shiyan,Hubei 442000,China)
出处
《湖北医药学院学报》
CAS
2021年第4期368-372,共5页
Journal of Hubei University of Medicine
基金
湖北省卫健委面上项目(WJ2017F072)
湖北省卫健委科研项目(ZY2021M006)。
关键词
进展性缺血性脑卒中
丹红注射液
通督调神针法
血脂代谢
炎性因子
Progressive ischemic stroke
Danhong injection
Tong Du regulating acupuncture
Blood lipid metabolism
Inflammatory Factors
