摘要
目的探讨经皮穴位电刺激辅助胸腔镜肺癌根治术对肺癌的近远期疗效。方法选取2019年1月至2020年6月间陕西省核工业二一五医院收治的124例肺癌患者,根据随机抽签法分为观察组与对照组,每组62例。均采用三孔胸腔镜肺癌根治手术治疗,对照组患者术后给予常规治疗,观察组患者在常规治疗的基础上给予经皮穴位电刺激治疗,治疗观察4周。结果两组患者手术时间、术中出血量和清扫淋巴结总数比较,差异无统计学意义(P>0.05)。观察组的术后胸管留置时间与术后住院时间均少于对照组,差异均有统计学意义(均P<0.05)。观察组术后4周的肺炎、肺漏气、心力衰竭和呼吸衰竭等并发症发生率为3.2%,低于对照组的19.4%,差异有统计学意义(P<0.05)。两组患者术后4周的血清三叶因子3(TFF3)水平高于术后1天,观察组的TFF3高于对照组,差异均有统计学意义(均P<0.05)。两组患者术后4周的白介素-32(IL-32)水平低于术前1天,观察组的IL-32低于对照组,差异均有统计学意义(均P<0.05)。随访时间截止到2021年4月,平均随访时间(13.72±1.14)个月,观察组的无瘤生存时间和总生存时间都长于对照组,差异均有统计学意义(均P<0.05)。结论经皮穴位电刺激辅助胸腔镜肺癌根治术应用于肺癌患者,能促进患者近期康复,减少并发症发生,抑制血清IL-32表达,促进TFF3表达,改善远期预后。
Objective To explore and observe the short-and long-term efficacy of percutaneous electrical acupoint stimulation adjunct to thoracoscopic radical resection of lung cancer.Methods From January 2019 to June 2020,124 patients with lung cancer were selected at NO.215 Hospital of Shaanxi Nuclear Industry.They were divided into an observation group and a control group with 62 patients in each groups accorded to the random lottery method.All patients underwent three-port thoracoscopic radical surgery for lung cancer.In addition,observation group received percutaneous electrical acupoint stimulation adjunct to thoracoscopic radical resection and the control group were given conventional treatment.The treatment was observed for 4 weeks.Results There were no significant difference in the duration of operation time,intraoperative blood loss,and total number of lymph nodes dissected between the two groups(P>0.05).The postoperative length of chest tube indwelling and postoperative length of hospital stay were less in the observation group than in the control group(all P<0.05).The incidence of complications such as pneumonia,lung air leakage,heart failure,and respiratory failure was 3.2%in the observation group at 4 weeks after surgery,which was lower than 19.4%of the control group(P<0.05).The serum Trefoil factor 3(TFF3)levels were higher in the two groups at 4 weeks after surgery than at 1 d after operation,and the level of TFF3 was higher in the observation group than in the control group(all P<0.05).Interleukin-32(IL-32)levels were lower at 4 weeks after surgery than at 1 day before operation with observation group lower than the control group(P<0.05).Patients were followed-up until April 2021.The average followedup time were 13.72±1.14 months.The tumor-free survival and overall survival were longer in the observation group than in the control group(all P<0.05).Conclusion Percutaneous electrical acupoint stimulation-assisted thoracoscopic radical lobectomy can promote short-term recovery,reduce occurrence of complication
作者
王鹏国
李小军
WANG Peng-guo;LI Xiao-jun(Department of Thoracic and Cardiovascular Surgery,NO.215 Hospital of Shaanxi Nuclear Industry,Xianyang 712000,China)
出处
《中国肿瘤临床与康复》
2021年第8期962-965,共4页
Chinese Journal of Clinical Oncology and Rehabilitation
关键词
三叶因子3
白介素-32
经皮穴位电刺激
胸腔镜肺癌根治术
近期疗效
远期疗效
Trefoil factor 3
Interleukin-32
Percutaneous electrical acupoint stimulation
Thoracoscopic radical resection of lung cancer
Short-term efficacy
Long-term efficacy
