摘要
Amphichoterpenoids A-C(1-3),unprecedented picoline-derived meroterpenoids possessing a pyrano[3,2-c]pyridinyl-g-pyranone scaffold,were characterized from the ascidian-derived fungus Amphichorda felina SYSU-MS7908.Their structures were elucidated by spectroscopic methods,X-ray diffraction and electronic circular dichroism(ECD)calculations.A plausible biosynthetic pathway was proposed.The isolated compounds displayed moderate inhibitory activity against acetylcholinesterase with 50%inhibiting concentration(IC_(50))values of 18.8-53.2 mmol/L.
基金
the National Natural Science Foundation of China(No.41806155)
the Guangdong MEPP Fund(No.GDOE(2019)A21)
the National Key R&D Program of China(No.2019YFC0312501)
the Natural Science Foundation of Guangdong Province(No.2018A030310304)
the Key-Area Research and Development Program of Guangdong Province(No.2020B1111030005)for generous support。
