摘要
目的探讨小剂量丙戊酸联合拉莫三嗪治疗癫痫的临床效果。方法选取2018年1月至2020年5月我院收治的80例癫痫患者作为研究对象,按照随机数字表法将其分为对照组和观察组,各40例。对照组采用小剂量丙戊酸治疗,观察组采用小剂量丙戊酸联合拉莫三嗪治疗。比较两组的临床疗效、癫痫发作情况、脑电图检查结果、认知功能评分、生活质量评分、不良反应发生情况。结果观察组的治疗总有效率为95.00%,高于对照组的77.50%(P<0.05)。治疗后,观察组的癫痫发作次数、痫样放电、累及导联数少于对照组,单次癫痫发作持续时间短于对照组(P<0.05)。治疗后,观察组的MoCA、MMSE评分高于对照组(P<0.05)。治疗后,观察组的生理、心理、环境、社会关系评分高于对照组(P<0.05)。两组的不良反应总发生率无显著差异(P>0.05)。结论小剂量丙戊酸联合拉莫三嗪治疗癫痫的效果显著,可控制癫痫发作,减少痫样放电,改善患者认知功能,提升生活质量,且不良反应少,安全性良好。
Objective To investigate the clinical effect of low dose valproic acid combined with lamotrigine in the treatment of epilepsy.Methods A total of 80 patients with epilepsy admitted in our hospital from January 2018 to May 2020 were selected as the research objects.The patients were divided into control group and observation group according to random number table method,with 40 cases in each group.The control group was treated with low dose valproic acid,and the observation group was treated with low dose valproic acid combined with lamotrigine.The clinical efficacy,seizures,EEG results,cognitive function score,quality of life score and adverse reactions were compared between the two groups.Results The total effective rate of treatment in the observation group was 95.00%,which was higher than 77.50%in the control group(P<0.05).After treatment,the number of seizures,epileptiform discharges and the number of involved leads in the observation group were less than those in the control group,and the duration of a single seizure was shorter than that in the control group(P<0.05).After treatment,the scores of MoCA and MMSE in the observation group were higher than those in the control group(P<0.05).After treatment,the scores of physiology,psychology,environment and social relations in the observation group were higher than those in the control group(P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion Low dose valproic acid combined with lamotrigine in the treatment of epilepsy has a significant effect,it can control epilepsy,reduce epileptiform discharge,ameliorate patients'cognitive function and improve their quality of life,with less adverse reactions and good safety.
作者
张申
张红霞
郭亚珂
ZHANG Shen;ZHANG Hongxia;GUO Yake(Neuroelectrophysiology Department,Zhengzhou Central Hospital Affiliated to Zhengzhou University,Zhengzhou 450007,China)
出处
《临床医学研究与实践》
2021年第25期91-93,共3页
Clinical Research and Practice
关键词
癫痫
丙戊酸
拉莫三嗪
epilepsy
valproic acid
lamotrigine
