摘要
目的:探究拉莫三嗪单药治疗癫痫的临床疗效和安全性。方法:124例癫痫患者,随机分为拉莫三嗪治疗组和丙戊酸钠治疗组,观察治疗后的6个月和12个月癫痫发作情况、生活质量评分和不良反应。结果:拉莫三嗪治疗组患者治疗后6个月和12个月的癫痫发作次数少于丙戊酸钠组患者,但差距无统计学意义(P>0.05)。拉莫三嗪组治疗癫痫患者完全控制的患者多于丙戊酸钠组患者,总有效率高于丙戊酸钠组患者,但差距无统计学意义(P>0.05)。拉莫三嗪治疗的癫痫患者在治疗后6个月和12个月的生活质量评分改善情况明显优于丙戊酸钠组,差距有统计学意义(P<0.05);不良反应:拉莫三嗪治疗组少于丙戊酸钠组,有统计学差异(P<0.05)。结论:癫痫患者在药物治疗方面使用拉莫三嗪的疗效显著,控制癫痫发作的效果理想,不良反应少,并在一定程度上提高癫痫患者的生活质量。
Objective： To explore the clinical effect and safety of lamotrigine treatment for epilepsy.Methods： 124 patients with epilepsy,respectively,given lamotrigine and sodium valproate treatment,observation after treatment of 6 months and one year epilepsy,life quality score and adverse reactions.Results： Lamotrigine treatment group patients after 6 months,and 12 months of epileptic seizure frequency is less than that of sodium valproate group of patients,gap have not statistical significance（P0.05）.Lamotrigine treatment group with epilepsy patients with complete control than sodium valproate group of patients,the total effective rate is higher than that of the same sodium valproate group of patients,but had no significant difference（P0.05）.Lamotrigine therapy in the treatment of patients with epilepsy after 6 months,and 12 months to improve the quality of life score situation is obviously superior to the sodium valproate treat patients,gap have statistical significance（P0.05）.The adverse reactions of lamotrigine group were lower than sodium valproate group,which had statistical differences（P0.05）.Conclusion： Patients with epilepsy in drug treatment use lamotrigine of curative effect is distinct,the control of seizures effect is ideal,the adverse reactions were less,and to some extent could improve the quality of life of patients with epilepsy.
出处
《现代生物医学进展》
CAS
2013年第16期3095-3098,共4页
Progress in Modern Biomedicine
关键词
拉莫三嗪
丙戊酸钠
癫痫
生活质量评分
发作控制率
临床疗效
Lamotrigine
Sodium valproate
Epilepsy
Life quality score
Seizure control rate
Clinical effect
