摘要
骨关节炎(osteoarthritis,OA)为一种退行性疾病,以关节软骨损害为主,常累及整个关节组织。其病理特点为关节软骨退化损伤,关节边缘和软骨下骨反应性增生。临床表现主要为关节的肿痛、僵硬甚至畸形。其确切的发病机制尚未明确。临床治疗方法包括基础治疗、药物治疗、修复性治疗、重建治疗、中医治疗等,随着基因学、免疫学、生物力学等学科的不断发展,新的治疗方法不断涌现。
Osteoarthritis,as a kind of inflammatory disease caused by a variety of reasons,would involve articular cartilage,bone and surrounding tissues eventually.It often occurs in the middle-aged and elderly,and its incidence is increasing along with the aging population in China.Meanwhile,it poses a threat to the quality of life and global public health.At present,the pathogenesis of osteoarthritis is still unclear,while early symptomatic treatment and surgery at the late stage are applied.Deficiencies are observed,although new treatment methods are emerging with the development of medical technology.This paper will present the latest research progress and treatment measures of osteoarthritis.
作者
耿宗洁
冀全博
王岩
GENG Zong-jie;JI Quan-bo;WANG Yan(Department of Orthopaedics,General Hospital of Chinese People's Liberation Army,Beijing,100853,China)
出处
《中国骨与关节杂志》
2021年第8期636-640,共5页
Chinese Journal of Bone and Joint
基金
国家自然科学基金(81672195、81902250)。
关键词
关节疾病
骨关节炎
治疗学
综述
Joint diseases
Osteoarthritis
Therapeutics
Review
