摘要
目的:为临床使用冲击波治疗膝关节骨性关节炎(KOA)提供循证医学证据。方法:2名研究员独立检索常用数据库知网、维普、万方、Sinomed、PubMed中以冲击波治疗KOA为随机对照研究的文献。采用Jadad评分表进行文献质量评价,RevMan5.3软件进行Meta分析。结果:15个随机对照试验,包含1248例患者最终被纳入。Meta分析结果显示:冲击波治疗膝骨关节炎临床有效率可靠[RR=1.12,95%CI(1.03,1.20),P=0.005],对于KOA患者的疼痛视觉模拟评分(VAS)[MD=-1.73,95%CI(-2.31,-1.14),P<0.00001]、Lequesne骨关节炎严重度指数[MD=-1.60,95%CI(-2.55,-0.64),P=0.001]及关节炎指数评分(WOMAC)[MD=-6.03,95%CI(-9.49,-2.57),P=0.0006]三大评分方面均有一定的改善,无危急不良反应事件。结论:现阶段证据表明,冲击波对于KOA患者疼痛等相关症状具有可靠疗效,临床推荐使用。
Objective:To provide evidence-based evidence for the clinical use of shockwave therapy in knee osteoarthritis(KOA).Methods:Two researchers independently searched the randomized controlled study of shockwave therapy for KOA in the databases of CNKI,VIP,WanFang Data,Sinomed and PubMed.Jadad rating scale was used for literature quality evaluation,and the extracted data was meta-analyzed by RevMan5.3 software.Results:A total of 15 randomized controlled trials involving 1248 patients were included.The results of meta-analysis showed The clinical effective rate of shock wave therapy for knee osteoarthritis was reliableRR=1.12,95%CI(1.03,1.20),P=0.005,and the efficacy was reliable in reducing the visual analogue scale MD=-1.73,95%CI(-2.31,-1.14),P=0.001,Lequesne osteoarthritis severity indexMD=-1.60,95%CI(-2.55,-0.64),P=0.001 and WOMACMD=-6.03,95%CI(-9.49,-2.57),P=0.0006 of KOA patients,without serious adverse reactions.Conclusion:At present,the evidence shows that shock wave can effectively improve the pain and other related symptoms in KOA patients,and the curative effect is reliable.
作者
曾凡
王康
卢敏
ZENG Fan;WANG Kang;LU Min(Hunan University of Traditional Chinese Medicine,Changsha 410208,Hunan,China;The First Affiliated Hospital of Hunan University of Traditional Chinese Medicine,Changsha 410007,Hunan,China)
出处
《海南医学院学报》
CAS
2020年第12期932-937,共6页
Journal of Hainan Medical University
基金
国家自然科学基金项目(81874476)
湖南省自然科学基金项目(2018JJ2303)。
关键词
膝骨关节炎
冲击波
META分析
Knee osteoarthritis
Shockwave therapy
Meta analysis
