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丙泊酚用于胸腔镜肺癌根治术患者的效果及对肿瘤微转移的评估

Effect of propofol on patients undergoing thoracoscopic radical resection of lung cancer and evaluation of tumor micrometastasis
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摘要 目的分析丙泊酚用于胸腔镜肺癌根治术患者的效果及其对肿瘤微转移的影响.方法选取本院收治的60例行胸腔镜肺癌根治术患者,按照随机数字表法分为丙泊酚组和七氟醚组,每组30例.麻醉诱导完成后,丙泊酚组予以靶控丙泊酚维持麻醉,七氟醚组予以持续吸入七氟醚进行维持麻醉.比较两组不同时间点血流动力学、脑电双频指数以及肺特异性X蛋白(LUNX)、细胞角蛋白19(CK19)阳性表达情况.结果两组患者麻醉诱导前、手术开始60min、手术结束时、术后24h舒张压、收缩压以及心率比较无明显差异(P>0.05).两组患者麻醉诱导前、手术开始60min、手术结束时脑电双频指数比较均无明显差异(P>0.05).两组患者麻醉诱导前、手术结束时、术后24h时CK19阳性率比较均无明显差异(P>0.05);术后48h,丙泊酚组LUNX和CK19阳性率明显低于七氟醚组(P<0.05).结论七氟醚与丙泊酚麻醉维持均可维持胸腔镜肺癌根治患者血流动力学稳定,确保麻醉深度适宜,但丙泊酚未提高患者术后LUNX、CK19阳性表达率,可能降低了术后肿瘤微转移发生风险,值得临床重视.
出处 《首都食品与医药》 2021年第14期49-51,共3页 Capital Food Medicine
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