摘要
目的探讨多模态影像锝亚甲基二膦酸盐(^(99)Tc^(m)-MDP)单光子发射计算机断层成像术(SPECT)/CT骨显影联合磁共振成像(MRI)对退行性骨关节炎(OA)的临床价值。方法搜集53例OA及33例骨关节正常的患者行^(99)Tc^(m)-MDP SPECT/CT骨显影,对研究关节行SPECT/CT融合断层显影,利用勾画感兴趣区技术(ROI)测定各骨关节最大放射性计数,获得异常关节组和正常关节组的半定量靶/非靶(T/NT)放射性计数比值。在前后2周内完成MRI检查。结合临床资料、影像检查及随访结果进行统计对比分析,2组比值进行t检验,同时2种影像检查行χ^(2)检验。结果53例OA中46例放射性摄取为不均匀中高度浓聚,其关节放射性计数均值为(4.39±2.02),另7例轻度浓聚为稳定性骨质增生。33例正常组关节均值为(1.43±0.29),2组比较差异有统计学意义(t=-10.29,P<0.05)。MRI显示OA多为骨髓水肿、软骨水肿、毛糙、关节腔积液、周围软组织改变等异常信号。2种影像方法在OA诊断方面比较差异无统计学意义(χ^(2)=0.70,P>0.05),但侧重关节病变不同方面。结论多模态影像SPECT/CT骨显影联合MRI对OA的活动性病灶诊断、评估及随访复查具有重要临床价值及指导意义。
Objective To investigate the clinical value of multimodal technetium-99m-methylene diphosphonate(^(99)Tc^(m)-MDP)single-photon emission computed tomography(SPECT)/CT bone imaging combined with magnetic resonance imaging(MRI)in the treatment of degenerative osteoarthropathy(OA).Methods A total of 53 patients with OA and 33 patients with normal joints underwent ^(99)Tc^(m)-MDP SPECT/CT bone imaging,SPECT/CT fusion tomography was performed on the studied joint,determination of the maximum radioactivity count(Max count)of each bone joint using the delineated region of interest(ROI)technique.The semi-quantitative target/non-target(T/NT)radioactivity count ratio of abnormal and normal joint groups was obtained.MRI was completed within 2 weeks.The clinical data,imaging examination and follow-up results were statistically compared and analyzed,t test was performed for the ratio of the two groups,and chi-square test was performed for both images.Results Of the 53 patients with OA,46 had uneven moderate to high concentration of radioactive uptake.The mean joint radioactivity count was(4.39±2.02).The other 7 patients with mild concentration were stable bone hyperplasia.The mean joint value of 33 patients in the normal group was(1.43±0.29).There were statistically significant differences between the two groups(t=-10.29,P<0.05).MRI showed that OA was mostly abnormal signals such as bone marrow edema,cartilage edema,roughness,joint cavity effusion,and surrounding soft tissue changes.There was no statistical difference between the two imaging methods in OA diagnosis(χ^(2)=0.70,P>0.05),but focused on different aspects of joint disease.Conclusion Multimodal SPECT/CT bone imaging combined with MRI has important clinical value and guiding significance in the diagnosis,evaluation and follow-up review of OA active lesions.
作者
汪建强
陈春梦
廖杰
Wang Jianqiang;Chen Chunmeng;Liao Jie(Department of Nuclear Medicine,the Second People's Hospital of Yibin,Sichuan 644000,China)
出处
《实用医技杂志》
2021年第9期1065-1068,F0003,共5页
Journal of Practical Medical Techniques
