摘要
目的探究与分析运用五运六气方药治疗糖尿病肾病的临床效果。方法选取聊城市中医医院2019年6月至2020年6月收治的120例糖尿病肾病患者,采用随机数字表法将其分为对照组和观察组,每组各60例。对照组实施常规药物治疗,观察组加用五运六气方药治疗,两组均连续治疗6个月。比较两组临床疗效、中医证候积分、肾功能指标、炎症因子水平的差异。结果观察组总有效率高于对照组,差异有统计学意义(P<0.05)。治疗后,两组中医证候积分、血肌酐(SCr)、尿素氮、24 h尿蛋白(24hUP)、血清白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)、C反应蛋白(CRP)水平均低于治疗前,且观察组中医证候积分、SCr、尿素氮、24hUP、IL-6、TNF-α、CRP水平均低于对照组,差异有统计学意义(P<0.05)。结论运用五运六气方药治疗糖尿病肾病的临床效果突出,在缓解相关症状及体征方面具有优势性,同时可促进改善肾功能指标及炎症状态。
Objective To explore and analyze the clinical effect of the formula of five evolutive phases and six climatic factors in the treatment of patients with diabetic nephropathy.Methods A total of 120 patients with diabetic nephropathy admitted to Liaocheng Traditional Chinese Medicine Hospital in Shandong Province from June 2019 to June 2020 were divided into control group and observation group by random number table method,with 60 cases in each group.The control group was treated with conventional drugs,and the observation group was treated with the formula of five evolutive phases and six climatic factors.Both groups were treated continuously for six months.Clinical efficacy,traditional Chinese medicine syndrome score,renal function index,and inflammatory factor levels were compared between the two groups.Results The total effective rate of the observation group was higher than that of the control group,and the difference was statistically significant(P<0.05).After treatment,the levels of traditional Chinese medicine syndrome score,serum creatinine(SCr),urea nitrogen,24 h urinary protein(24hUP),serum interleukin-6(IL-6),tumor necrosis factor-α(TNF-α),and C-reactive protein(CRP)in two groups were all lower than before treatment,and the levels of traditional Chinese medicine syndrome score,SCr,urea nitrogen,24hUP,IL-6,TNF-α,and CRP in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).Conclusion The clinical effect of treating diabetic nephropathy with the formula of five evolutive phases and six climatic factors is outstanding,which has prominent advantages in relieving related symptoms and signs,and at the same time can promote the improvement of renal function indicators and inflammatory state.
作者
郑晓东
张娜娜
冯燕
ZHENG Xiaodong;ZHANG Nana;FENG Yan(Department of Endocrinology,Liaocheng Traditional Chinese Medicine Hospital,Shandong Province,Liaocheng 252000,China;Operating Room,Liaocheng Traditional Chinese Medicine Hospital,Shandong Province,Liaocheng 252000,China)
出处
《中国医药导报》
2021年第24期64-67,共4页
China Medical Herald
基金
全国中医临床特色技术传承骨干人才培训项目(国中医药人教函〔2019〕36号)。
关键词
五运六气方药
糖尿病肾病
疗效
肾功能
炎症状态
Formula of five evolutive phases and six climatic factors
Diabetic nephropathy
Curative effect
Renal function
Inflammatory state
