摘要
目的观察钙磷代谢指标在腹膜透析高磷血症患者治疗中的变化。方法选取2018年7月至2019年12月在本院行维持性腹膜透析并发高磷血症的患者共计60例,用随机数字表法分为2组,对照组30例给予醋酸钙治疗;研究组30例给予碳酸司维拉姆治疗。比较2组血钙、血磷、钙磷乘积、全段甲状旁腺激素(iPTH)、低密度脂蛋白胆固醇(LDL⁃C)水平和碳酸氢盐浓度。结果两组组内不同时间点的血钙、血磷、钙磷乘积、iPTH水平比较,差异有统计学意义(P<0.05),治疗前,两组血钙、血磷、钙磷乘积、iPTH水平组间比较,差异无统计学意义(P>0.05),治疗4、8周后,研究组血钙、血磷、钙磷乘积、iPTH水平均低于对照组,差异有统计学意义(P<0.05)。对照组组内不同时间点LDL⁃C、碳酸氢盐浓度水平比较,差异无统计学意义(P>0.05),研究组组内不同时间点LDL⁃C、碳酸氢盐浓度水平比较,差异有统计学意义(P<0.05),治疗前、治疗4周后,两组LDL⁃C、碳酸氢盐浓度水平组间比较,差异无统计学意义(P>0.05),治疗8周后,研究组LDL⁃C低于对照组,差异有统计学意义(P<0.05),碳酸氢盐浓度高于对照组,差异有统计学意义(P<0.05)。结论司维拉姆适用于治疗腹膜透析高磷血症,能纠正钙磷代谢紊乱,调节LDL⁃C与碳酸氢盐浓度。
Objective To observe the changes of calcium and phosphorus metabolism indexes in the treatment of patients with peritoneal dialysis hyperphosphatemia.Methods From July 2018 to December 2019,a total of 60 patients with hyperphosphatemia undergoing maintenance peritoneal dialysis in our hospital were selected and divided into two groups by random number table.30 cases in the control group were treated with calcium acetate;30 patients in the study group were treated with sevelamer carbonate.The blood calcium,blood phosphorus,calcium⁃phosphorus product,intact parathyroid hormone(iPTH)expression level,low⁃den⁃sity lipoprotein cholesterol(LDL⁃C),and bicarbonate concentration were compared between the two groups.Results There was a statistically significant difference in blood calcium,blood phosphorus,calcium⁃phospho⁃rus product,and iPTH levels at different time points between the two groups(P<0.05).Before treatment,there was no significant between the two groups of blood calcium,blood phosphorus,calcium⁃phosphorus product,and iPTH levels(P>0.05).After 4 weeks of treatment and 8 weeks of treatment,the study group's blood calcium,blood phosphorus,calcium⁃phosphorus product,and iPTH levels were lower than those of the control group,the difference was statistically significant(P<0.05).There was no significant difference in LDL⁃C and bicarbonate concentration levels at different time points in the control group(P>0.05).There was statistically significant difference in LDL⁃C and bicarbonate concentration levels at different time points in the study group(P<0.05).Before treatment and after 4 weeks of treatment,there was no significant difference in LDL⁃C and bicarbonate levels between the two groups(P>0.05).After 8 weeks of treatment,the LDL⁃C of the study group was lower than that of the control group,the difference was statistically significant(P<0.05),the bicar⁃bonate concentration was higher than that of the control group,the difference was statistically significant(P<0.05).Conclusion Sevelamer i
作者
胡天晓
马欣
HU Tianxiao;MA Xin(The First Department of Nephrology,Handan Central Hospital,Handan,Hebei,China,056001;Department of Pharmacy,Handan Central Hospital,Handan,Hebei,China,056001)
出处
《分子诊断与治疗杂志》
2021年第8期1247-1250,共4页
Journal of Molecular Diagnostics and Therapy
基金
河北省医学科学研究课题计划(20191839)。
关键词
司维拉姆
腹膜透析
高磷血症
血磷
甲状旁腺激素
Sevelamer
Peritoneal dialysis
Hyperphosphatemia
Blood phosphorus
Parathyroid hormone
