摘要
目的:观察黄母二白汤对肾病综合征伴水肿症状患儿临床症状及血生化、尿生化指标水平的影响。方法:选取84例肾病综合征伴水肿症状患儿为研究对象,随机分为对照组与观察组各42例。对照组接受常规治疗,观察组在对照组基础上联合黄母二白汤治疗。比较2组治疗有效率;比较2组治疗前后中医证候积分、血小板计数(BPC)、D-二聚体(DD)、纤维蛋白原(FIB)、活化部分凝血活酶时间(APTT)、凝血酶原时间(PT)及24 h尿蛋白量(24 hUP)、血肌酐(SCr)、尿素氮(BUN)、肌酐清除率(CCr);统计2组治疗及随访期间水肿复发率及并发症发生率。结果:观察组总有效率为97.62%,高于对照组的85.71%(P<0.05)。与同组治疗前比较,治疗后2组各项中医证候积分、DD、FIB、24 hUP、SCr及BUN均降低(P<0.05),APTT、PT、CCr均升高(P<0.05);与对照组治疗后比较,观察组治疗后各项中医证候积分、DD、FIB、24 hUP、SCr及BUN均较低(P<0.05),APTT、PT、CCr均较高(P<0.05)。随访期间对照组水肿复发率为33.33%,高于观察组的7.32%(P<0.05)。治疗及随访期间观察组并发症发生率为4.76%,低于对照组的19.05%(P<0.05)。结论:黄母二白汤治疗肾病综合征伴水肿症状患儿疗效显著,可明显改善患儿临床症状、降低水肿复发率及并发症发生率。
Objective:To observe the effect of Huangmu Erbai tang on clinical symptoms,blood biochemical indexes and urinary biochemical indexes of children with nephrotic syndrome complicated with edema.Methods:A total of 84 cases of children with nephrotic syndrome complicated with edema were selected as the study objects,and randomly divided into the control group and the observation group,42 cases in each group.The control group was given routine treatment,and the observation group was additionally treated with Huangmu Erbai tang based on the treatment of the control group.The curative effective rate was compared between the two groups.Before and after treatment,Chinese medicine syndrome scores,platelet count blood(BPC),D-dimer(D-D),fibrinogen(FIB),activated partial thromboplastin time(APTT),prothrombin time(PT),the content of 24-hour urine protein(24 hUP),serum creatinine(SCr),blood urea nitrogen(BUN),and creatinine clearance rate(CCr)were compared between the two groups.The recurrence rate of edema and the incidence of complications were counted in the two groups during treatment and follow-up.Results:The total effective rate was 97.62% in the observation group,higher than that of 85.71%in the control group(P<0.05).When compared with those before treatment in the same group,Chinese medicine syndrome scores,DD,FIB,24 h UP,SCr,and BUN in the two groups were decreased after treatment(P<0.05),and levels of APTT,PT,and CCr were increased(P<0.05).After treatment,when compared with those in the control group,Chinese medicine syndrome scores,DD,FIB,24 h UP,SCr,and BUN in the observation group were lower after treatment(P<0.05),and levels of APTT,PT,and CCr were higher(P<0.05).During the follow-up,the recurrence rate of edema was 33.33% in the control group,higher than that of 7.32% in the observation group(P<0.05).During treatment and follow-up,the incidence of complications was 4.76% in the observation group,lower than that of 19.05% in the control group(P<0.05).Conclusion:Huangmu Erbai tang has a significant curative effect
作者
卢书芳
赵丹
王宏磊
孟牛安
杨之藻
LU Shufang;ZHAO Dan;WANG Honglei;MENG Niu'an;YANG Zhizao
出处
《新中医》
CAS
2021年第15期56-60,共5页
New Chinese Medicine
基金
河南省科技攻关项目(132102310129)。
关键词
肾病综合征
黄母二白汤
水肿
儿童
生化指标
Nephrotic syndrome
Huangmu Erbai tang
Edema
Children
Biochemical indexes
