摘要
抗生素抗性基因(ARGs)和重金属抗性基因(HRGs)已被普遍视为新型环境污染物,二者之间存在联合抗性机制。因此,抗生素和重金属联合污染下细菌的抗性研究受到了广泛关注。总结了细菌中ARGs和HRGs的来源,综述了协同抗性、交叉抗性、协同调控抗性和生物被膜抗性4种联合抗性机制,并对今后的研究方向进行了展望,对新型抗菌药物的开发、解释或推测联合抗性发生的原因具有一定的指导意义。
Antibiotics resistance genes(ARGs)and heavy metals resistance genes(HRGs)are considered as emergent environmental pollutants commonly.Environmental bacteria are generally exposed to combinations of these pollutants.Therefore,the study of bacterial resistance under the co-contamination of antibiotics and heavy metals has attracted extensive attention.The origin of ARGs and HRGs in bacteria was summarized.4 co-contaminated resistance mechanisms,namely co-resistance mechanism,cross-resistance mechanism,co-regulation resistance mechanism and biofilm resistance mechanism were reviewed.The future research directions were prospected.It had important significance for the development of new antibacterial agent and explanation for co-contaminated resistance mechanisms.
作者
戎玲玲
王复标
吴礼贵
冯关萍
肖小雨
邹小明
RONG Lingling;WANG Fubiao;WU Ligui;FENG Guanping;XIAO Xiaoyu;ZOU Xiaoming(College of Life Sciences,Jinggangshan University,Ji’an Jiangxi 343009)
出处
《环境污染与防治》
CAS
CSCD
北大核心
2021年第8期1062-1068,1076,共8页
Environmental Pollution & Control
基金
江西省教育厅科技计划青年项目(No.GJJ190569)
井冈山大学博士科研启动项目(No.JZB1901)
江西省自然科学基金资助项目(No.20181BAB203023、No.20192BAB214014)
江西省博士后择优资助项目(No.2019KY48)
邹小明杰出青年人才资助计划项目(No.20192BCBL23014)。
关键词
协同抗性
交叉抗性
协同调控抗性
生物被膜抗性
co-resistance
cross-resistance
co-regulation resistance
biofilm resistance
