摘要
目的:研究保元血府逐瘀方加减治疗对慢性心力衰竭(CHF)气虚血瘀证患者血清心肌酶谱及心肌钙蛋白(cTn)水平的影响。方法:选择本院2018年9月~2020年1月诊治的87例气虚血瘀证CHF患者,随机信封法分为对照组(42例)和观察组(45例),前者给予常规西药治疗,后者在其基础上联合保元血府逐瘀方加减治疗。比较两组患者治疗前后血清心肌酶谱水平、cTnI、N端脑钠肽前体(NT-proBNP)、心功能、血流动力学和中医证候积分,并评估疗效。结果:观察组患者的治疗有效率显著高于对照组(P<0.05);治疗后,观察组中医证候积分、心肌酶谱各项指标水平显著低于对照组(P<0.05);治疗前两组患者cTnI和NT-proBNP水平比较显著差异(P>0.05),治疗后观察组水平显著低于对照组(P<0.05);治疗前两组患者心功能水平比较无显著差异(P>0.05),治疗后观察组左心室射血分数(LVEF)水平显著高于对照组,左心室舒张/收缩末期内径(LVEDd、LVESd)水平显著低于对照组(P<0.05);治疗前两组患者血流动力学指标水平无显著差异(P>0.05),治疗后观察组外周阻力水平显著低于对照组,心排出量、每搏输出量(SV)水平显著高于对照组(P<0.05)。结论:保元血府逐瘀方加减治疗气虚血瘀证CHF患者可保护心肌,促进心脏供血能力的提高以及心功能的恢复,从而提高整体疗效。
Objective:To study the effect of Modified Baoyuan Xuefu Zhuyu Recipe on levels of serum myocardial enzymes and cardiac troponin(cTn)for patients with chronic heart failure(CHF)of Qi-deficiency blood-stasis syndrome.Methods:A total of 87 CHF patients of Qi-deficiency blood-stasis syndrome who were diagnosed and treated in the hospital from September 2018 to January 2020 were randomly divided into a controlled group(42 cases,routine western medicine)and a study group(45 cases,Modified Baoyuan Xuefu Zhuyu Recipe on the basis of the controlled group)by envelop method.The levels of serum myocardial enzymes,cTnI and N-terminal pro-brain natriuretic peptide(NT-proBNP),cardiac function,hemodynamics and scores of TCM syndromes before and after treatment were compared between the two groups.And the curative effect was evaluated.Results:The response rate of treatment in the study group was significantly higher than that in the controlled group(P<0.05).After treatment,scores of TCM syndromes and levels of myocardial enzymes in the study group were significantly lower than those in the controlled group(P<0.05).Before treatment,there were no significant differences in levels of cTnI and NT-proBNP between the two groups(P>0.05),which were significantly lower in the study group than the controlled group after treatment(P<0.05).Before treatment,there was no significant difference in cardiac function level between the two groups(P>0.05).After treatment,left ventricular ejection fraction(LVEF)in the study group was significantly higher than that in the controlled group,while left ventricular end-diastolic dimension and left ventricular end systolic diameter(LVEDd,LVESd)were significantly lower than those in the controlled group(P<0.05).Before treatment,there were no significant differences in levels of hemodynamics indexes between the two groups(P>0.05).After treatment,peripheral resistance level in the study group was significantly lower than that in the controlled group,while cardiac output and stroke volume(SV)were significantly
作者
邓林杰
车瑾
DENG Linjie;CHE Jin(Department of Cardiology,Guanggu District,the Third Hospital of Wuhan City,Wuhan Hubei 430000,China;Department of Integrated Chinese and Western Medicine,the Third Hospital of Wuhan City,Wuhan Hubei 430061,China)
出处
《四川中医》
2021年第8期59-63,共5页
Journal of Sichuan of Traditional Chinese Medicine
关键词
保元血府逐瘀方
慢性心力衰竭
气虚血瘀证
心肌酶谱
心肌钙蛋白
Baoyuan Xuefu Zhuyu Recipe
Chronic heart failure
Qi-deficiency blood-stasis syndrome
Myocardial enzyme
Cardiac troponin
