摘要
目的:探讨18F-脱氧葡萄糖(FDG)正电子发射断层成像/计算机断层扫描(PET/CT)代谢参数预测弥漫大B细胞淋巴瘤(DLBCL)患者预后的价值。方法:回顾性分析治疗前接受18F-FDG PET/CT检查并经病理确诊的58例DLBCL患者的临床资料,分析最大标准摄取值(SUV_(max))、肿瘤代谢体积(MTV)和病灶糖酵解总量(TLG)与临床因素的关系。采用Kaplan-Meier法、Log-rank检验及多因素COX回归分析代谢SUV_(max)、MTV和TLG与总生存时间(OS)和无进展生存时间(PFS)的关系。结果:58例DLBCL患者的SUV_(max)、MTV和TLG分别为21.45(10.26-42.38)、27.30(14.20-133.25)cm^(3)和322.85(47.35-1 438.20)。单因素分析显示,大肿块、Ann Arbor分期、国际预后指数、MTV及TLG是DLBCL患者OS和PFS的影响因素(P<0.05),而乳酸脱氢酶及SUV_(max)仅是PFS的影响因素(P<0.05)。多因素分析显示,MTV(HR=2.974,95%CI:1.803-7.225)(/HR=3.925,95%CI:1.973-8.246)及TLG(HR=2.583,95%CI:1.192-5.316)/(HR=2.874,95%CI:1.538-6.483)是影响DLBCL患者OS和PFS的独立危险因素(P<0.05),国际预后指数(HR=2.490,95%CI:1.150-4.962)是影响DLBCL患者OS的独立危险因素(P<0.05)。结论:MTV及TLG是影响DLBCL患者OS和PFS的独立危险因素,对DLBCL患者预后判断具有一定的参考价值。
Objective: To investigate the prognostic value of metabolic parameters of 18F-fluorodeoxyglucose(18F-FDG)positron emission tomography/computed tomography(PET/CT) in diffuse large B-cell lymphoma(DLBCL). Methods:The clinical data of 58 patients with DLBCL who were examined by 18F-FDG PET/CT before treatment and confirmed by pathology were analyzed retrospectively. The relationships between maximum standardized uptake value(SUV_(max)),metabolic tumor volume(MTV), total lesion glycolysis(TLG) and clinical factors were analyzed. Kaplan Meier method,Log-rank test and multivariate Cox regression were used to analyze the relationships between metabolic SUV_(max), MTV,TLG and times of total overall survival(OS) and progression-free survival(PFS). Results: The SUV_(max), MTV and TLG of 58 DLBCL patients were 21.45(10.26-42.38), 27.30(14.20-133.25) cm^(3) and 322.85(47.35-1438.20), respectively.Univariate analysis showed that large mass, Ann Arbor stage, international prognostic index, MTV and TLG were the factors influencing OS and PFS in DLBCL patients(P<0.05), while lactate dehydrogenase and SUV_(max) were the factors influencing PFS only(P<0.05). Multivariate analysis showed that MTV(HR=2.974, 95%CI: 1.803-7.225)/(HR=3.925,95%CI: 1.973-8.246) and TLG(HR=2.583, 95%CI: 1.192-5.316)/(HR=2.874, 95%CI: 1.538-6.483) were independent risk factors for OS and PFS in DLBCL patients(P<0.05), and international prognostic index(HR=2.490, 95%CI: 1.150-4.962) was independent risk factor for OS in DLBCL patients(P<0.05). Conclusion: MTV and TLG are independent risk factors for OS and PFS in patients with DLBCL, which may be valuable for prognosis of patients with DLBCL.
作者
苏洁敏
郑庆中
黄文荣
邓菁
吴军
卢宏全
SU Jie-Min;ZHENG Qing-Zhong;HUANG Wen-Rong;DENG Jing;WU Jun;LU Hong-Quan(Department of Radiology,Hainan West Central Hospital,Danzhou 571799,Hainan Province,China;Department of Hematology,Hainan West Central Hospital,Danzhou 571799,Hainan Province,China)
出处
《中国实验血液学杂志》
CAS
CSCD
北大核心
2021年第4期1181-1186,共6页
Journal of Experimental Hematology
