摘要
目的:分析血糖控制不良妊娠期糖尿病(GDM)孕妇血清富亮氨酸α-2糖蛋白1(LRG1)水平与早期肾损伤指标的相关性。方法:选择2017年3月-2019年4月于本院就诊的GDM孕妇及健康孕妇为研究对象,分为血糖控制良好组、血糖控制不良组和对照组,将血糖控制不良组分为LRG1≥270组与LRG1<270组,比较组间血糖、胰岛素(FINS)及早期肾损伤指标。结果:血清LRG1、尿素氮(BUN)、血清肌酐(Cr)、尿微量白蛋白(UmAlb)、尿微量白蛋白/肌酐(ACR)值GDM孕妇中血糖控制不良组大于血糖控制良好组及对照组(P<0.05),血糖控制良好组与对照组血无差异(P>0.05);血糖控制不良孕妇中,FINS、HOMA-IR值、BUN、Cr、UmAlb、ACR值等LRG1≥270组大于LRG1<270组(P<0.05),FPG、HbA1c值两组无差异(P>0.05);血糖控制不良孕妇血清LRG1值与UmAlb、ACR呈正相关关系(P<0.001),与FINS、HOMA-IR、BUN、Cr值无相关性(P>0.05)。结论:血糖控制不良的GDM孕妇血清LRG1与早期肾损伤指标存在相关性,LRG1有望成为GDM预测孕妇早期肾损伤的新型血清标志物。
Objective:To analyze the correlation between serum leucine-rich-2 glycoprotein 1(LRG1)level of pregnant women with gestational diabetes mellitus(GDM)and poor glucose control and their early renal injury.Methods:Pregnant women with GDM were selected in study group and healthy pregnant women were selected in control group from March 2017 to April 2019.The women in the study group were divided into group A(women with good blood glucose control)and group B(women with poor blood glucose control).The women in group B were further divided into group B 1(women with LRG1 level≥270)and group B2(women with LRG1 level<270).The indexes of blood glucose,insulin,and early renal injury of the women were compared among these groups.Results:The levels of serum LRG1,urea nitrogen(BUN),creatinine(Cr),and urine microalbumin(UmAlb),and urinary micro albumin/creatinine rate(ACR)value of the women in group A were significant higher than those of the women in group B and the control group(P<0.05),but which had was no significant difference between group A and the control group(P>0.05).The values of FINS,HOMA-IR and ACR,and the levels of BUN,Cr,and UmAlb of the women in group B1 were significant higher than those of the women in group B2(P<0.05),but there were no significant different in the levels of FPG and HbA1c of the women between group B1 and group B2(P>0.05).The serum LRG1 level of the women in group B was positively correlated with their UmAlb level and ACR value(P<0.001),but which had no correlation with the FINS,BUN,and Cr levels and the HOMA-IR value(P>0.05).Conclusion:The serum LRG1 level of pregnant women with GDM and poor glucose control is correlated with their early renal injury index,which is expected to be the new serum marker for predicting early renal injury of pregnant women with GDM.
作者
王远远
WANG Yuanyuan(Wuyi People's Hospital, Jinhua, Zhejiang Province, 321200)
出处
《中国计划生育学杂志》
2021年第7期1484-1487,共4页
Chinese Journal of Family Planning
