摘要
人口老龄化使骨性疾病发生率逐年升高。中药单药及复方防治老年骨性疾病具有整体调节、副作用小、疗效确切等优势,因作用于不同的器官及组织,从多途径、多环节、多靶点上发挥药物治疗作用,故其作用机制较为复杂。网络药理学作为一门新型学科,可预测中药活性成分及疾病靶点,富集相关通路,系统评价中药治病的作用机制。本文主要综述网络药理学在骨质疏松症(OP)、骨性关节炎(OA)及老年腰椎间盘突出症(LDH)等疾病中的应用概况,为中医药防治老年骨性疾病的实验研究提供参考思路。
The aging of the population has increased the incidence of bone diseases year by year.Traditional Chinese have the advantages of overall regulation,small side effects,and accurate curative effects in the prevention and treatment of senile bone diseases. The mechanism is more complicated,because they act on different organs and tissues,and play a role in drug treatment from multiple channels,multiple links and multiple targets. As a new discipline,network pharmacology can predict the active ingredients and disease targets of traditional Chinese medicine,enrich related pathways,and systematically evaluate the mechanism of treatment of traditional Chinese medicine.the application of network pharmacology are reviewed in osteoporosis,osteoarth ritis,and lumbar disc herniation. It provides a reference for the experimental research of traditional Chinese medicine on the prevention and treatment of senile bone diseases.
作者
海云翔
宋敏
蒋宜伟
董万涛
HAI Yunxiang;SONG Min;JIANG Yiwei;DONG Wantao(Clinical College of TCM,Gansu University of Traditional Chinese Medicine,Lanzhou 730000,China;Department of Joint Surgery,the second Affiliated Hospital of Gansu University of Traditional Chinese Medicine,Lanzhou 730020,China)
出处
《中央民族大学学报（自然科学版）》
2021年第3期75-80,共6页
Journal of Minzu University of China(Natural Sciences Edition)
基金
国家自然科学基金委地区基金项目(81760876)
甘肃省中医药防治慢性疾病重点实验室开放基金项目(GSMBKY2015-07)。
关键词
网络药理学
中医药
老年骨性疾病
研究进展
network pharmacology
traditional Chinese medicine
Senile bone diseases
research progress
