摘要
肿瘤的发生发展和侵袭与表观遗传学变化紧密相关。胞嘧啶甲基化产物5-甲基胞嘧啶(5-methylcytosine,5-mC)是重要的表观遗传学调控因子。羟甲基化是5-mC去甲基化的重要过程之一,其产物5-羟甲基胞嘧啶(5-hydroxy-methylcytosine,5-hmC)也参与基因的表观遗传学调控。国内外研究提示,5-hmC表达水平及分布的改变与胚胎发育、肿瘤发生发展等密切相关。本文对5-hmC及其在肿瘤中的异常与肿瘤关系的研究进展进行综述。
The occurrence,development and invasion of tumors are closely related to epigenetic changes.5-Methylcytosine(5-mC),a product of cytosine methylation,is an important epigenetic regulator.Hydroxymethylation is one of the important processes of 5-mC demethylation,and its product 5-hydroxymethylcytosine(5-hmC)is also involved in the epigenetic regulation of genes.Multiple studies at domestic and foreign suggest that the changes of 5-hmC level and distribution are closely related to embryonic development and tumorigenesis.This article reviews the research progress of 5-hmC and its abnormality in tumor and its relationship with tumor.
作者
刘双庆
车德海(综述)
孟庆威(审校)
LIU Shuangqing;CHE Dehai;MENG Qingwei(Department of Medicine Oncology,Harbin Medical University Cancer Hospital,Harbin 150086,China)
出处
《实用肿瘤学杂志》
CAS
2021年第4期386-390,共5页
Practical Oncology Journal
关键词
肿瘤
DNA羟甲基化
5-hmC
Tumor
DNA hydroxymethylation
5-Hydrosymethylcytosine
