摘要
沙门氏菌感染猪后,宿主的免疫应答是决定感染结局的关键因素。在感染早期,机体通过激活天然免疫来抵抗沙门氏菌感染。由于沙门氏菌可以通过分泌毒力因子等来逃避宿主的杀菌作用,因此,需要进一步启动获得性免疫应答,才能有效地杀灭细菌,其中,T、B淋巴细胞介导的免疫应答在清除病原体方面的作用尤为重要。论文通过对猪免疫系统和沙门氏菌感染引起的免疫应答情况的综述,以期为沙门氏菌感染的免疫防控提供理论依据。
The pig's immune response is a key factor in determining the outcome of the Salmonella infection.In the early stage of infection,pig resists Salmonella infection by activating innate immunity.Because Salmonella can escape the clearance of host through secreting virulence factors,it is necessary to further initiate adaptive immunity.Among them,the immune response mediated by T and B lymphocytes plays a particularly important role in eliminating pathogens.This article summarized the immune system of pigs and the immune response caused by Salmonella infection,hoping to provide a theoretical basis for the immune prevention and control of Salmonella infection.
作者
赵歌
胡茂志
葛浩杰
孟闯
焦新安
潘志明
ZHAO Ge;HU Mao-zhi;GE Hao-jie;MENG Chuang;JIAO Xin-an;PAN Zhi-ming(Jiangsu Provincial Key Laboratory of Zoonosis,Yangzhou University,Yangzhou Jiangsu,225009,China;Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses,Yangzhou University,Yangzhou Jiangsu,225009,China;Key Laboratory of Prevention and Control of Biological Hazard Factors(Animal Origin)for Agri food Safety and Quality in the Ministry of Agriculture and Rural Affairs,Yangzhou University,Yangzhou,Jiangsu,225009,China;Joint Laboratory of International Cooperation in Agriculture and Agricultural Products Safety,Yangzhou University,Yangzhou Jiangsu,225009,China)
出处
《动物医学进展》
北大核心
2021年第8期83-87,共5页
Progress In Veterinary Medicine
基金
国家重点研发计划项目(2018YFD0500502)
江苏省高校自然科学研究重大项目(20KJA230002)
扬州大学科技创新团队(2016)
江苏省高校优势学科建设工程项目(PAPD)。
关键词
沙门氏菌
天然免疫
获得性免疫
猪
Salmonella
innate immunity
adaptive immunity
pig
