摘要
目的:探讨参芪扶正注射液联合尼莫地平治疗脑梗死恢复期的疗效及其对患者神经认知功能、血液流变学、T细胞亚群的影响。方法:选取杭州市中医院2016年4月至2019年12月诊治的脑梗死恢复期患者108例,采用随机数字表法分为对照组(尼莫地平治疗)和研究组(对照组基础上联合参芪扶正注射液治疗),每组54例。比较两组疗效及治疗前后神经认知功能、血液流变学、T细胞亚群的变化。结果:研究组总有效率为90.74%(49/54),高于对照组的75.93%(41/54)(χ^(2)=4.267, P=0.039)。治疗2周后,研究组全血高切黏度为(4.17±0.24)mPa/s、全血低切黏度为(9.27±1.98)mPa/s、血浆黏度为(1.07±0.19)mPa/s,均低于对照组的(4.52±0.31)mPa/s、(13.69±2.13)mPa/s、(1.34±0.23)mPa/s( t=6.560、11.169、6.651,均 P<0.05);研究组CD_(3)^(+)为(48.59±4.59)%、CD_(4)^(+)为(44.24±6.17)%、CD_(4)^(+)/CD_(8)^(+)为(1.91±0.17),均高于对照组的(44.97±5.31)%、(39.55±5.13)%、(1.47±0.22)( t=3.790、4.295、11.629,均 P<0.05);研究组CD_(8)^(+)为(23.13±5.62)%,低于对照组的(26.97±4.26)%( t=4.001, P<0.05);研究组简易智力状态检查表(MMSE)评分为(28.87±0.85)分,高于对照组的(27.91±1.45)分( t=4.197, P<0.05),研究组美国国立卫生研究院卒中量表(NIHSS)评分为(9.63±2.19)分,低于对照组的(15.27±1.97)分( t=14.070, P<0.05)。 结论:参芪扶正注射液联合尼莫地平能显著改善脑梗死恢复期患者神经认知功能、血液流变学及T细胞亚群,且安全可靠,疗效稳定。
Objective To investigate Shenqi Fuzheng Injection combined with nimodipine in the treatment of convalescent-phase cerebral infarction and its effects on neurocognitive function,hemorheology and T cell subsets.Methods A total of 108 patients with cerebral infarction in the convalescent phase who received treatment in Hangzhou Hospital of Traditional Chinese Medicine,China between April 2016 and December 2019 were included in this study.They were randomly assigned to receive either nimodipine treatment(control group,n=54)or treatment with Shenqi Fuzheng Injection combined with nimodipine(study group,n=54).Curative effects and changes in neurocognitive function,hemorheology and T cell subsets after treatment relative to before treatment were compared between the control and study groups.Results Total effective rate in the study group was significantly higher than that in the control group[90.74%(49/54)vs.75.93%(41/54),χ^(2)=4.267,P=0.039].After 2 weeks of treatment,whole blood viscosity at a high shear rate,whole blood viscosity at a low shear rate,plasma viscosity in the study group were(4.17±0.24)mPa/s,(9.27±1.98)mPa/s,(1.07±0.19)mPa/s,respectively,which were significantly lower than those in the control group[(4.52±0.31)mPa/s,(13.69±2.13)mPa/s,(1.34±0.23)mPa/s,t=6.560,11.169,6.651,all P<0.05].The proportion of CD_(3)^(+)cells,CD_(4)^(+)and CD_(4)^(+)/CD_(8)^(+)in the study group was(48.59±4.59)%,(44.24±6.17)%and(1.91±0.17)respectively,which were significantly higher than those in the control group[(44.97±5.31)%,(39.55±5.13)%,(1.47±0.22),t=3.790,4.295,11.629,all P<0.05].The proportion of CD_(8)^(+)cells in the study group was significantly lower than that in the control group[(23.13±5.62)%vs.(26.97±4.26)%,t=4.001,P<0.05].Mini-Mental State Examination score in the study group was significantly higher than that in the control group[(28.87±0.85)points vs.(27.91±1.45)points,t=4.197,P<0.05].National Institute Health of Stroke Scale score in the study group was significantly lower than that in the contr
作者
申友奎
王雁秋
李军
叶琦
董勇
鲍光明
Shen Youkui;Wang Yanqiu;Li Jun;Ye Qi;Dong Yong;Bao Guangming(Department of Brain Surgery,Hangzhou Hospital of Traditional Chinese Medicine,Hangzhou 310007,Zhejiang Province,China)
出处
《中国基层医药》
CAS
2021年第8期1159-1163,共5页
Chinese Journal of Primary Medicine and Pharmacy
基金
浙江省医学会临床科研资金项目(2017ZYC-B4)。
关键词
脑梗塞
恢复期
参芪扶正注射液
血液流变学
尼莫地平
认知
T淋巴细胞亚群
疗效比较研究
Brain infarction
Convalescence
Henqi fuzheng injection
Nimodipine
Cognition
Hemorheology
T-Lymphocyte subsets
Comparative effectiveness research
