摘要
目的观察2型糖尿病周围血管病变(DPVD)患者太极拳锻炼后病变的改善情况,探讨太极拳锻炼对DPVD炎症的作用机制。方法研究选择2018年1月至2019年3月河南理工大学第一附属医院内分泌科收治的DPVD患者66例,采用随机数字表将66例患者随机分为对照组和太极拳组,各33例。对照组患者给予降糖、降脂等基础治疗,太极拳组患者在对照组的治疗基础上应用太极拳锻炼,检测两组患者治疗后生命质量各领域的得分及治疗前后双侧腘动脉和足背动脉管径、流速;血糖,糖化血红蛋白(Hb A1c)水平和血清肿瘤坏死因子-α(TNF-α),白细胞介素-6(IL-6)及高敏C反应蛋白(hs-CRP)水平。结果 (1)太极拳组生命质量中生理领域、心理领域、社会关系领域、环境领域评分明显提高。(2)治疗前后腘动脉、足背动脉管径及流速比较,太极拳组明显改善。(3)治疗后空腹血糖、餐后2 h血糖及Hb A1c水平,太极拳组明显改善。(4)治疗前后太极拳组血清TNF-α、IL-6、hs-CRP水平分别为(16.98±3.86/7.68±1.31)pg/L、(12.14±0.61/8.14±0.79)pg/L、(8.26±0.79/5.49±0.63)mg/L,对照组分别为(17.57±3.91/10.40±1.29)pg/L、(11.93±0.72/10.12±0.82)pg/L、(8.06±0.80/6.37±0.64)mg/L,太极拳组显著降低,差异均有统计学意义(P<0.05或P<0.01)。结论 DPVD患者应用太极拳锻炼与单独用药相比,可明显提高患者生活质量,改善患者腘动脉和足背动脉管径、流速,血糖及Hb A1c水平;降低患者血清中TNF-α、IL-6、hs-CRP水平。
Objective To observe the improvement of patients with type 2 diabetic peripheral vascular disease(DPVD)after Tai Chi exercise,and to explore the working mechanism of Tai Chi exercise on DPVD inflammation.Methods A total of 66 patients with DPVD admitted to the Department of Endocrinology,No.1 Affiliated Hospital of Henan Polytechnic University from January 2018 to March 2019 were selected.The 66 patients were randomly divided into control group and Tai Chi group using a random number table,with 33 patients in each group.Patients in the control group were given basic treatment such as hypoglycemic and lipid-lowering,and patients in the Tai Chi group were given Tai Chi exercise on the basis of the treatment in the control group.The scores of life quality in various fields,as well as the diameter and velocity of bilateral popliteal artery and dorsal foot artery before and after treatment in the two groups were detected.Blood glucose,glycosylated hemoglobin(HbA1c)and serum tumor necrosis factor-α(TNF-α),interleukin-6(IL-6)and high-sensitivity C-reactive protein(hs-CRP)levels were also derected.Results①The scores of physiological field,psychological field,social relationship field and environmental field in the Tai Chi group were significantly improved.②The diameter and velocity of popliteal artery and dorsal foot artery before and after treatment were significantly improved in Tai Chi group.③After treatment,the levels of fasting blood glucose,2 h postprandial blood glucose and HbA1c were significantly improved in the Tai Chi group。④Before and after treatment,the levels of serum TNF-α,IL-6,and hs-CRP in the Tai Chi group were respectively(16.98±3.86/7.68±1.31)pg/L,(12.14±0.61/8.14±0.79)pg/L,and(8.26±0.79/5.49±0.63)mg/L,while they were(17.57±3.91/10.40±1.29)pg/L,(11.93±0.72/10.12±0.82)pg/L,(8.06±0.80/6.37±0.64)mg/L respectively in the control group.It was significantly decreased in the Tai Chi group,with statistical significance(P<0.05 or P<0.01).Conclusion Compared with single medication,Tai C
作者
周清安
王献红
祝希泉
衣志爽
杨利杰
王林
李春梅
李红艳
Zhou Qing'an;Wang Xianhong;Zhu Xiquan;Yi Zhishuang;Yang Lijie;Wang Lin;Li Chunmei;Li Hongyan
出处
《中国疗养医学》
2021年第10期1025-1028,共4页
Chinese Journal of Convalescent Medicine
基金
军区后勤科研计划项目(JN13W027)
新乡医学院三全学院应用型课题项目(XJKT201923)。
关键词
2型糖尿病
周围血管病变
太极拳
临床疗效
作用机制
Type 2 diabetic peripheral vascular disease(DPVD)
Tai Chi
Clinical effect
Working mechanism
