摘要
锌指蛋白是人类基因组中规模最大的转录因子家族,锌指结构的多种组合方式决定其在生物学行为上表现出不同功能。关于不同锌指蛋白在恶性肿瘤癌变过程中的作用机制尚待进一步研究。作者简要阐述了C2H2型锌指蛋白在转录调节和翻译后修饰的作用机制并总结其在不同肿瘤中的调控作用。
Zinc finger proteins are the largest family of transcription factors in the human genome.Various combinations of zinc finger structures determine different functions in biological behavior,including regulation of gene expression,cell differentiation and embryonic development at the level of transcription and translation.The mechanism of action of different zinc finger proteins in the malignant process of cancer needs to be further studied.In this article,the mechanism of C2H2 zinc finger protein transcription regulation and post-translational modification was briefly reviewed,and its regulatory roles in different tumors were summarized.
作者
韩小暖
陈浩暘
张忠
薄威
HAN Xiaonuan;CHEN Haoyang;ZHANG Zhong;BO Wei(The First Delivery Room,Shengjing Hospital Affiliated to China Medical University,Shenyang,Liaoning,110000;Pathological Teaching and Research Office of Shenyang Medical College,Shenyang,Liaoning,110032)
出处
《实用临床医药杂志》
CAS
2021年第13期110-114,共5页
Journal of Clinical Medicine in Practice
基金
辽宁省科学技术计划项目(20170540885)
沈阳医学院青年科学研究基金项目(20202025)。
关键词
锌指蛋白
C2H2型
转录因子
肿瘤
基因调控
乙酰化
zinc finger protein
C2H2 type
transcription factor
tumor
gene regulation
acetylation
