摘要
目的研究百合科沿阶草属植物麦冬Ophiopogon japonicus的化学成分。方法利用HPD100、硅胶、Sephadex LH-20、ODS等多种柱色谱及制备液相色谱进行分离纯化,通过理化数据和现代波谱分析技术对化合物进行结构鉴定。结果从麦冬提取物中分离得到17个化合物,分别鉴定为甲基麦冬黄烷酮A(1)、甲基麦冬黄烷酮B(2)、5,7-二甲氧基-3-(4-羟基苄基)-4-苯并二氢吡喃酮(3)、胡萝卜苷(4)、β-谷甾醇(5)、1-龙脑6-O-β-D-呋喃芹糖-(1→6)-β-D-吡喃葡萄糖苷(6)、ophiogenin(7)、薯蓣皂苷元(8)、黄卡瓦胡椒素C(9)、3,4-二羟基烯丙基苯(10)、邻苯二甲酸二丁酯(11)、对羟基苯甲醛(12)、三环蛇麻二醇(13)、4(15)-桉叶烯-1β,6α-二醇(14)、香草酸(15)、cyperusol C(16)、(2aS,3aS)-lyciumamide D(17)。结论化合物3、9~11、13、14、16、17为首次从该植物中分离得到。
Objective To study the chemical constituents of Ophiopogon japonicus.Methods Compounds were isolated and purified from O.japonicus by various chromatographic techniques such as HPD100,silica gel,Sephadex LH-20,and ODS as well as preparative HPLC.Their structures were identified by physicochemical data and modern spectral analysis techniques.Results Seventeen compounds were isolated from the extract of O.japonicus,and identified as methylophiopogonanone A(1),methylophiopogonanone B(2),5,7-dimethoxy-3-(4-hydroxybenzyl)-4-chromanone(3),daucosterol(4),β-sitosterol(5),1-borneol 6-O-[β-D-apiofuranosyl-(1→6)]-β-D-glucopyranoside(6),ophiogenin(7),diosgenin(8),flavokawain C(9),3,4-dihydroxyallyl benzene(10),dibutyl phthalate(11),p-hydroxybenzaldehyde(12),tricyclohumuladiol(13),1β,6α-dihydroxyeudesma-4(15)-ene(14),vanillic acid(15),cyperusol C(16),and(2a S,3a S)lyciumamide D(17).Conclusion Compounds 3,9—11,13,14,16,17 are isolated from this plant for the first time.
作者
李小辉
袁名睿
陆雪萍
陆礼和
李战国
梅双喜
王京昆
董汛
LI Xiao-hui;YUAN Ming-rui;LU Xue-ping;LU Li-he;LI Zhan-guo;MEI Shuang-xi;WANG Jing-kun;DONG Xun(Yunnan Bai Yao Group Innovation and R&D Center,Yunnan Key Laboratory for TCM and Ethnic Drug of New Drug Creation,Yunnan Institute of Materia Medica,Kunming 650111,China)
出处
《中草药》
CAS
CSCD
北大核心
2021年第13期3804-3809,共6页
Chinese Traditional and Herbal Drugs
基金
云南省2019年中药饮片产业发展专项(2019-YG-010)。
