摘要
目的:运用中医传承辅助平台数据挖掘功能,探索《古今医统大全》中治疗咳嗽的组方的用药规律,深入研究经典中医药治疗咳嗽的组方思路及对新药的研发提供基础和动力。方法:应用中医传承辅助系统软件,采用软件集成的关联规则分析、复杂系统熵聚类及无监督的熵层次聚类等数据挖掘方法,分析《古今医统大全》治疗咳嗽的高频药物及组合、药物归经和归类、核心药物组合等,并生成新处方。结果:对搜集、筛选出的97个治疗咳嗽处方进行输入分析,发现共涉及133味中药,高频药物(频次≥10)25味,高频药物组合(频次≥20)16组,演化得到核心组合8个、新处方8首。结论:《古今医统大全》中治疗咳嗽方剂以治肺为主,重视从脾胃论治咳嗽,选用药物以补虚药及化痰止咳平喘药为主。
Objective:The medication laws for cough in Gujin Yitong Daquan(《古今医统大全》)were explored by the data mining,in order to further study the formulation ideas for cough,and to provide the foundation and motivation for the research and development of new medicines.Methods:Through data mining methods such as association rule analysis,complex system entropy clustering,and unsupervised entropy hierarchical clustering,the high-frequency medicines and combinations,meridian and classification of the medicines,and the core medicine combinations,etc.used to treat cough in Gujin Yitong Daquan were analyzed,and new prescriptions were generated in this article.Results:97 prescriptions for cough were selected and analyzed,involving 133 TCM medicines.25 high frequency(frequency≥10)herbs and 16 high frequency(frequency≥20)TCM herbs combinations were extracted.8 core TCM herbs combinations and 8 new prescriptions were obtained.Conclusion:In Gujin Yitong Daquan,the main prescription for cough is to treat the lung;it is important to treat cough from the spleen and stomach.The selected medicines are mainly used to tonify deficiency,resolve phlegm,and relieve cough and asthma.
出处
《中医临床研究》
2021年第14期14-17,共4页
Clinical Journal Of Chinese Medicine
基金
国家自然科学基金资助项目,扶正剔邪搜络方对肺纤维化不同时相肺血管新生的调控及机制研究(81473657)。
