摘要
目的探讨在慢性牙周炎临床治疗中采用丁硼乳膏联合奥硝唑治疗的临床效果及对炎性因子的改善作用。方法 100例(160颗患牙)慢性牙周炎患者,根据入院日期的单双号分为对照组(80颗患牙)与观察组(80颗患牙),各50例。对照组单用奥硝唑片治疗,观察组采用丁硼乳膏联合奥硝唑治疗。比较两组临床疗效、视觉模拟评分法(VAS)评分、牙周指标、白细胞介素-6(IL-6)、白细胞介素-8(IL-8)、肿瘤坏死因子-α(TNF-α)、不良反应发生情况。结果观察组治疗总有效率98.00%高于对照组的84.00%,差异有统计学意义(P<0.05)。治疗后,观察组VAS评分(2.72±0.32)分低于对照组的(3.36±0.38)分,差异有统计学意义(P<0.05)。治疗后,观察组牙龈指数、菌斑指数、探针深度和牙周附着水平分别为(0.75±0.15)、(1.38±0.21)、(3.15±0.25)mm、(4.17±0.51)mm,均低于对照组的(1.11±0.18)、(1.81±0.27)、(4.25±0.26)mm、(5.59±0.72)mm,差异有统计学意义(P<0.05)。治疗后,观察组IL-6、IL-8、TNF-α水平分别为(16.26±2.32)ng/ml、(5.36±1.25)pg/ml、(24.45±3.25)pg/ml,均低于对照组的(24.54±3.35)ng/ml、(9.05±1.56)pg/ml、(31.28±4.29)pg/ml,差异有统计学意义(P<0.05)。观察组不良反应发生率4.00%低于对照组的18.00%,差异有统计学意义(P<0.05)。结论在慢性牙周炎临床治疗中使用丁硼乳膏联合奥硝唑,可显著提高慢性牙周炎患者临床疗效,减轻其疼痛度,促进其牙周指标及炎性因子水平的有效改善,同时可降低不良反应发生率,临床应用价值显著。
Objective To investigate the clinical effects and the improvement of inflammatory factors of Ding Peng cream combined with ornidazole in the treatment of chronic periodontitis.Methods 100 patients(160 teeth)with chronic periodontitis were divided into a control group(80 teeth)and an observation group(80 teeth)according to the odd and even numbers of their admission date,with 50 patients in each group.The control group was treated with ornidazole tablets alone,and the observation group was treated with a combination therapy of Ding Peng cream and ornidazole.Clinical efficacy,Visual Analogue Scale(VAS)score,periodontal indexes,interleukin-6(IL-6),interleukin-8(IL-8),tumor necrosis factor-α(TNF-α),incidence of adverse reactions were compared between the two groups.Results The overall clinical efficacy in the observation group was 98.00%,which was higher than 84.00%in the control group,and the difference was statistically significant(P<0.05).After treatment,VAS score in the observation group was(2.72±0.32)points,which was lower than(3.36±0.38)points in the control group,and the difference was statistically significant(P<0.05).After treatment,the observation group had a gingival index of(0.75±0.15),a plaque index of(1.38±0.21),a probing depth of(3.15±0.25)mm and a periodontal attachment level of(4.17±0.51)mm,which were lower than corresponding(1.11±0.18),(1.81±0.27),(4.25±0.26)mm,(5.59±0.72)mm in the control group,and the difference was statistically significant(P<0.05).After treatment,the observation group had IL-6 level of(16.26±2.32)ng/ml,IL-8 level of(5.36±1.25)ng/ml,TNF-αlevel of(24.45±3.25)ng/ml,which were lower than corresponding(24.54±3.35)ng/ml,(9.05±1.56)pg/ml,(31.28±4.29)pg/ml in the control group,and the difference was statistically significant(P<0.05).The incidence of adverse reactions in the observation group was 4.00%,which was lower than 18.00%in the control group,and the difference was statistically significant(P<0.05).Conclusion In the clinical treatment of chronic periodontitis,th
作者
吕海秀
LYU Hai-xiu(Department of Stomatology,Kouzhen Street Community Health Service Center in Laiwu District,Jinan 271114,China)
出处
《中国实用医药》
2021年第22期26-29,共4页
China Practical Medicine
关键词
丁硼乳膏
奥硝唑
慢性牙周炎
牙周指标
炎性因子
Ding Peng cream
Ornidazole
Chronic periodontitis
Periodontal index
Inflammatory factor
