摘要
目的 观察盐酸米诺环素缓释剂对慢性牙周炎患者龈沟液中白细胞介素-6（IL-6）水平的影响。方法 120例慢性牙周炎患者按照治疗方式不同分为两组,对照组60例,采用口服替硝唑治疗,治疗组60例,采用局部应用盐酸米诺环素缓释剂治疗。治疗前后测定患者的菌斑指数、牙周袋探诊深度、探诊出血率和龈沟液的IL-6。结果 治疗2周后,两组PLI、PD、BOP均较治疗前差异有统计学意义（P＜0.05,P＜0.01）,且治疗组改善更明显（均P＜0.05）。治疗前,对照组IL-6水平为（8.07±1.17）pg/L,治疗组IL-6水平为（8.13±1.29）pg/L;治疗后,两组分别为（6.78±1.13）pg/L、（5.62±1.09）pg/L,两组治疗前后差异均有统计学意义（均P＜0.01）,且治疗组比对照组降低更明显（P＜0.05）。结论 盐酸米诺环素缓释剂可以通过降低慢性牙周炎患者炎性反应。
Objective To observe the effect of minocycline hydrochloride sustained-release agent on interleukin-6（IL-6） in gingival sulcus fluid of patients with chronic periodontitis.Methods One hundred and twenty patients with chronic periodontitis were randomly divided into two groups,the control group（n=60 cases） and the treatment group（n=60 cases）.The patients in the control group were treated through oral tinidazole.The patients in the treatment group were given topical application of minocycline hydrochloride sustained-release agent.The plaque index,probing pocket depth,bleeding on probing rate and IL-6 in gingival sulcus fluid were detected before and after treatment.Results The plaque index,probing pocket depth,bleeding on probing rate were decreased after treatment.There was a significant difference between two groups（P〈0.05）.IL-6 level was decreased after treatment.There was a significant difference between two groups（P〈0.05）.Conclusion Minocycline hydrochloride can improve patients with chronic periodontitis through mitigating inflammation.
出处
《中国基层医药》
CAS
2013年第12期1786-1788,共3页
Chinese Journal of Primary Medicine and Pharmacy
