摘要
隐匿性丙型肝炎(OCI)是指在血清/血浆中检不出HCV RNA,而存在于肝细胞和外周血单个核细胞(PBMC)中。OCI存在于普通人群和无偿献血者中及其传染性和经输血传播风险已得到证实。采供血机构的血液筛查无论是酶免法还是核酸检测,检测标本均为血浆/血清,无法检出PBMC中的HCV RNA,OCI已成为输血安全的潜在威胁,需要研发行之有效的检测和传播阻断技术。
Occult hepatitis C infection(OCI)is defined as HCV RNA not detected in serum or plasma but in hepatocytes and peripheral blood mononuclear cells(PBMCs).OCI exists in general population and voluntary blood donors,and its infectivity and risk of transmission by transfusion has been confirmed.HCV RNA in PBMCs could not be detected in plasma or serum by blood screening in transfusion services,neither by enzyme-linked immunosorbent assay nor by nucleic acid amplification testing.OCI has become a potential threat to transfusion safety,therefore effective detection technologies and transmission blocking strategies need to be further developed.
作者
赵会霞
孙书芳
王同显
ZHAO Huixia;SUN Shufang;WANG Tongxian(Qingdao Blood Center,Qingdao 266071,China)
出处
《中国输血杂志》
CAS
2021年第7期793-796,共4页
Chinese Journal of Blood Transfusion
基金
青岛市中心血站科技支持项目[2017-xz07]。
