摘要
目的:探究泌尿系结石患者尿路感染病原菌的分布特征和耐药情况。方法:选取医院2019年1月—2020年6月收治350例泌尿系结石患者的临床资料,统计其清洁中段尿标本中细菌培养及药敏试验结果,分析其尿路感染的病原菌分布特征及其耐药情况。结果:350例泌尿系结石患者中,79例患者发生尿路感染,其发生率为22.57%;在尿路感染患者的尿液标本中,检出致病菌79株,其中革兰阴性菌占68.35%、革兰阳性菌占17.72%、真菌占11.39%以及脲原体感染占2.53%;药敏试验结果显示,革兰阴性菌中大肠埃希菌对哌拉西林、氨苄西林、阿莫西林、替卡西林、莫西沙星、环丙沙星、复方磺胺甲噁唑的耐药率均较高(大于70.00%),对亚胺培南、美罗培南、哌拉西林-他唑巴坦钠、阿莫西林-克拉维酸钾、阿米卡星的敏感率均较高(大于85.00%);革兰阳性菌中屎肠球菌对青霉素、庆大霉素、氨苄西林、苯唑西林的耐药率均较高(大于70.00%),对呋喃妥因、万古霉素、氨苄西林-舒巴坦钠、哌拉西林-他唑巴坦钠、利奈唑胺、左氧氟沙星、莫西沙星的敏感率均较高(大于78.00%)。结论:泌尿系结石伴尿路感染的病原菌主要为革兰阴性菌,其次为革兰阳性菌、真菌,极少数为脲原体;临床应根据药敏试验结果合理选用抗菌药物治疗,以确保良好的抗菌疗效。
Objective: To investigate the distribution characteristics and drug resistance to pathogenic bacteria in urinary calculi patients with urinary tract infection. Methods: Clinical data of 350 patients with urinary calculi admitted to our hospital from January 2019 to June 2020 were selected. The results of bacterial culture and drug sensitivity test in clean middle urine samples were counted, and the distribution characteristics of pathogenic bacteria and drug resistance to urinary tract infection were analyzed. Results: Of the 350 patients with urinary calculi, 79 patients developed urinary tract infection(22.57%).In the urine samples of patients with urinary tract infection, 79 strains of pathogenic bacteria were detected, in which Gram-negative bacteria(68.35%), Gram-positive bacteria(17.72%), fungi(11.39%) and Ureaplasma infection(2.53%) were detected. Based on the results of drug sensitive test of Gram-negative bacterium E. coli to piperacillin, ampicillin, amoxicillin, ticarcillin, moxifloxacin and ciprofloxacin, have higher percentages of compound sulfamethoxazole(greater than 70%), of the imine southern culture, E.faecalis to amoxicillin clavulanic acid potassium, the sensitive rate of amikacin was high(greater than 85%);Enterococcus faecium in Gram-positive bacteria to penicillin, gentamicin, ampicillin and oxacillin, have higher percentages of schering(greater than 70%), with nitrofurantoin, vancomycin, ampicillin-sulbactam sodium, piperacillin-tazobactam sodium, linezolid, levofloxacin, moxifloxacin sensitive rates were high(greater than 78%). Conclusion: The pathogens of urinary calculi accompanied by urinary tract infection were mainly caused by Gram-negative bacteria, some patients were caused by Gram-positive bacteria and fungi, and a few patients were caused by ureaplasma infection. In order to ensure good antibacterial effect, antibacterials should be selected reasonably based on the results of drug sensitivity test.
作者
周航
吴石萍
谢明
简月晃
胡冬华
刘跃辉
ZHOU Hang;WU Shi-ping;XIE Ming;JIAN Yue-huang;HU Dong-hua;LIU Yue-hui(Department of Urology,Pingxiang No.3 People's Hospital,Pingxiang Jiangxi 337000,China)
出处
《抗感染药学》
2021年第5期644-647,共4页
Anti-infection Pharmacy
关键词
泌尿系结石
尿路感染
病原菌分布特征
耐药性
urinary calculi
urinary tract infection
distribution characteristics of pathogenic bacteria
drug resistance
