摘要
目的研究糖尿病足患者病原菌分布情况及其耐药性,为后续研究提供参考。方法选择2016年1月至2018年12月间在我院接受治疗的116例糖尿病足感染(DFI)患者为研究对象,患者入院后使用抗生素之前,在感染部位提取样本进行细菌检测,确定DFI感染病原菌特点及主要病原菌耐药情况。结果2016年收治的35例DFI患者病原菌检出率为71.43%。2017年收治的38例DFI患者病原菌检出率为71.05%。2018年收治的43例DFI患者病原菌检出率为72.09%。3年内DFI患者革兰阴性菌总阳性率呈下降趋势,革兰阳性菌总阳性率呈上升趋势。铜绿假单胞菌对庆大霉素及氨曲南耐药性最高,对丁胺卡霉素及亚胺培南耐药性最低,耐药性为0.00%。奇异变形菌对氨曲南耐药性最高,为46.15%,而对他唑巴坦、美罗培南、替卡西林、丁胺卡霉素及亚胺培南耐药性最低,均为0.00%。葡萄球菌对红霉素及青霉素G呈高耐药性,对亚胺培南及莫西沙星耐药性最低,均为0.00%。肠球菌对红霉素、丁胺卡霉素、头孢曲松耐药性均达100.00%,而对青霉素G、阿莫西林/棒酸的耐药性为0.00%。结论DFI患者病原菌分布会随时间变迁而改变,及时、反复的细菌培养和药敏试验是合理应用抗生素,减少细菌耐药性的前提,其在控制患者糖尿病足感染程度,改善患者预后中具有重要意义。
Objective To analyze the pathogenic bacteria distribution and antibiotic resistance of diabetic foot infection(DFI),so as to provide a reference for the following study.Methods A total of 116 patients with DFI treated in our hospital from January 2016 to December 2018 were enrolled.Before administration of antibiotics,samples were taken at the site of infection for bacterial testing.Then the characteristics of the pathogenic bacteria and the drug resistance status of the main pathogens of DFI were discussed.Results The detection rate of pathogenic bacteria was 71.43%in 35 DFI patients admitted in 2016,71.05%in 38 DFI patients admitted in 2017,and 72.09%in 43 DFI patients admitted in 2018.There was a decreasing trend in the total positive rate of gram-negative bacteria and an increasing trend in the total positive rate of gram-positive bacteria in DFI patients over a 3-year period.Pseudomonas aeruginosa had the highest resistance to Gentamicin and Aztreonam,and lowest resistance to Amikacin and Imipenem(0.00%).The resistance of Proteus mirabilis to Aztreonam was the highest,and those to Tazobactam,Meropenem,Ticarcillin,Amikacin and Imipenem were the lowest(0.00%).Staphylococcus was highly resistant to Erythromycin and Penicillin G and lowly resistant to Imipenem and Moxifloxacin with the drug resistance being 0.00%.The resistances of Enterococcus to Erythromycin,Amikacin and Ceftriaxone were 100.00%,and those to Penicillin G and Amoxicillin/Clavulanic acid were 0.00%.Conclusion The distribution of pathogenic bacteria in patients with DFI changes over time.Timely and repeated bacterial culture and drug sensitivity testing is a prerequisite for the rational application of antibiotics and the reduction of bacterial resistance,which is important in controlling the degree of infection in patients with diabetic foot and improving their prognosis.
作者
郝艳霞
白红艳
HAO Yan-xia;BAI Hong-yan(Department of Laboratory,Xingyuan Hospital,Yulin,Shaanxi 719000,China;不详)
出处
《中国微生态学杂志》
CAS
CSCD
2021年第6期695-698,共4页
Chinese Journal of Microecology
关键词
糖尿病足
病原菌分布
耐药性
Diabetic foot
Pathogen distribution
Drug resistance
