摘要
沉默调节蛋白6(SIRT6)具有去乙酰化酶、单ADP核糖基转移酶以及去脂肪酰化酶等多种功能,在调控多种生理及病理过程中发挥重要作用。概述了SIRT6的结构及生物学功能,详细介绍了SIRT6在病毒性肝炎、非酒精性脂肪性肝病、酒精性脂肪性肝病、肝硬化、肝癌等不同类型的肝脏疾病中的研究进展及相关作用分子机制。了解SIRT6在肝脏疾病中的作用,可能为肝病的治疗提供新思路及治疗靶点。
SIRT6 has the multiple functions of deacetylase,single ADP ribosyltransferase,and defatty acylase and plays an important role in the regulation of various physiological and pathological processes.This article summarizes the structure and biological functions of SIRT6 and introduces in detail the research advances in the role and molecular mechanisms of SIRT6 in different types of liver diseases such as viral hepatitis,nonalcoholic fatty liver,alcoholic fatty liver,liver cirrhosis,and liver cancer.An understanding of the role of SIRT6 in liver diseases may provide new ideas and targets for the treatment of liver diseases.
作者
方欢
钟晓琳
FANG Huan;ZHONG Xiaolin(School of Clinical Medicine,Southwest Medical University,Luzhou,Sichuan 646000,China;Department of Gastroenterology,The Affiliated Hospital of Southwest Medical University,Luzhou,Sichuan 646000,China)
出处
《临床肝胆病杂志》
CAS
北大核心
2021年第8期1975-1978,共4页
Journal of Clinical Hepatology
基金
四川省科技厅基金项目(2020YJ0190)
王宝恩肝纤维化研究基金项目(20200520)。
关键词
乙型肝炎
慢性
非酒精性脂肪性肝病
肝硬化
癌
肝细胞
抗衰老酶
Hepatitis B,Chronic
Non-Alcoholic Fatty Liver Disease
Liver Cirrhosis
Carcinoma,Hepatocellular
Sirtuins
