摘要
急性缺血性脑卒中是一类发病机制复杂,目前暂无有效治疗方法的一类疾病。沉默信息调节因子1(silent information regulator1,SIRT1)是一种依赖于烟酰胺腺嘌呤二核苷酸(nicotinamide adenine dinucleotide,NAD^(+))的去乙酰化酶,是衰老、凋亡等生理活动的重要调节因子之一。有研究表明,SIRT1与脑缺血再灌注损伤的神经保护作用密切相关,可能作为治疗急性缺血性脑卒中的新靶点。
Acute ischemic stroke is a kind of disease with complicated pathogenesis and no effective treatment at present.Silencing information regulator 1(SIRT1)is a nicotinamide adenine dinucleotide(NAD^(+))-dependent deacetylase,and is one of the important regulators of aging,apoptosis and other physiological activities.Studies have shown that SIRT1 is closely related to the neuroprotective effect of cerebral ischemia-reperfusion injury and may be a new target for the treatment of acute ischemic stroke.
作者
张佳秀
邹玉安
ZHANG Jia-xiu;ZOU Yu-an(Graduate School of Hebei North University,Zhangjiakou,075000,China;Department of Neurology,the First Affiliated Hospital of Hebei North University,Zhangjiakou,075000,China)
出处
《神经药理学报》
2020年第6期41-44,共4页
Acta Neuropharmacologica
