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补肾活血汤治疗骨质疏松性椎体压缩性骨折临床研究 被引量:5

Clinical Study on Bushen Huoxue Tang for Osteoporotic Vertebral Compression Fracture
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摘要 目的:观察补肾活血汤治疗骨质疏松性椎体压缩性骨折(OVCF)的临床疗效及对患者骨代谢的影响。方法:选取60例OVCF患者,随机分为观察组和对照组各30例。2组均行经皮椎体成形术(PVP)治疗,对照组术后3 d给予阿法骨化醇软胶囊治疗,观察组在对照组基础上加服补肾活血汤治疗。比较2组临床疗效及治疗前后疼痛程度、肢体功能、骨密度及骨代谢指标,记录2组不良反应。结果:观察组总有效率为90.00%,对照组总有效率为66.67%,2组比较,差异有统计学意义(P<0.05)。治疗后,2组视觉模拟评分法(VAS)、Oswestry功能障碍指数(ODI)评分均较治疗前降低(P<0.05),观察组VAS、ODI评分均低于对照组(P<0.05)。治疗后,2组L1~4及大粗隆骨密度均较治疗前增加(P<0.05),观察组L1~4及大粗隆骨密度均大于对照组(P<0.05)。治疗后,2组血清碱性磷酸酶(ALP)、骨钙素(BGP)及骨保护素(OPG)水平均较治疗前升高(P<0.05),尿脱氧吡啶酚(DPD)水平均较治疗前降低(P<0.05);观察组血清ALP、BGP及OPG水平均高于对照组(P<0.05),尿DPD水平低于对照组(P<0.05)。2组均未发生严重不良反应。结论:补肾活血汤治疗OVCF疗效显著,能有效缓解患者疼痛,改善其肢体功能及骨密度,促进骨生长,且安全性高。 Objective:To observe the clinical effect of Bushen Huoxue tang for osteoporotic vertebral compression fracture(OVCF)and its effect on bone metabolism.Methods:A total of 60 cases of OVCF patients were randomly divided into the observation group and the control group,30 cases in each group.Both groups were treated with percutaneous vertebroplasty(PVP).On the 3rd day after surgery,the control group was given alfacalcidol soft capsules,and the observation group was additionally given the oral administration of Bushen Huoxue tang based on the treatment of the control group.The clinical effect was compared between the two groups.Before and after treatment,pain degree,limb function,as well as the indexes of bone density and bone metabolism were compared between the two groups.The adverse reactions were recorded in the two groups.Results:The total effective rate was 90.00%in the observation group,and 66.67%in the control group,the difference being significant(P<0.05).After treatment,the scores of Visual Analogue Scale(VAS)and Oswestry dysfunction index(ODI)in the two groups were decreased when compared with those before treatment(P<0.05),and the two scores in the observation group were lower than those in the control group(P<0.05).After treatment,the bone densities of L1~4 and the greater trochanter were increased when compared with those before treatment(P<0.05),the bone densities and the greater trochanter in the observation group were larger than those in the control group(P<0.05).After treatment,levels of alkaline phosphatase(ALP),bone gammacarboxyglutamic acid-containing protein(BGP),and osteoprotegerin(OPG)in serum in the two groups were increased when compared with those before treatment(P<0.05),and levels of urine deoxypyridinoline(DPD)were decreased(P<0.05).After treatment,levels of ALP,BGP,and OPG in serum in the observation group were higher than those in the control group(P<0.05),and levels of DPD in urine were lower(P<0.05).No severe adverse reactions occurred in the two groups.Conclusion:Bushen Huoxue tang
作者 倪建光 NI Jianguang
机构地区 乐清市人民医院
出处 《新中医》 CAS 2021年第14期49-52,共4页 New Chinese Medicine
关键词 骨质疏松性椎体压缩性骨折 补肾活血汤 疼痛 肢体功能 骨密度 骨代谢 Osteoporotic vertebral compression fracture Bushen Huoxue tang Pain Limb function Bone density Bone mechanism
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