摘要
目的:探讨中性粒细胞淋巴细胞比值(NLR)、血小板淋巴细胞比值(PLR)在肺炎支原体(MP)感染患儿中的水平变化及意义。方法:277例呼吸道感染患儿作为观察组,收集同期109例体检健康的患儿作为对照组。根据MP-IgM检测结果将观察组分为肺炎支原体抗体阳性组和肺炎支原体抗体阴性组。比较三组NLR、PLR表达水平,建立Logistic回归模型,制作ROC曲线评估NLR、PLR预测MP感染的价值。结果:①肺炎支原体抗体阳性组NLR、PLR水平明显高于肺炎支原体抗体阴性组及对照组,差异均有统计学意义(均P<0.05);②Logistic回归分析结果显示,NLR、PLR可预测肺炎支原体感染的风险(P<0.05);③NLR、PLR单独检测及联合检测的ROC曲线下面积分别为0.709、0.683、0.717;NLR、PLR曲线下临界值为1.56、100.17,灵敏度53.3%、64.5%,特异度为82.5%、67.7%,两者联合检测的灵敏度69.8%,特异度70.96%。结论:NLR、PLR与MP感染密切相关,联合检测可提高对MP感染的预测效能,可给MP感染的诊断和治疗提供新线索。
Objective:To investigate the changes and significance of serum neutrophil-lymphocyte ratio(NLR)and platelet-lymphocyte ratio(PLT)in the children with mycoplasma pneumoniae infection.Methods:277 patients were selected as the observation group,and 109 children with healthy physical examination were selected as the control group.According to the MP-IgM detection result,the children in observation group were divided into mycoplasma pneumoniae positive group and mycoplasma pneumoniae negative group.The differences in NLR and PLR were compared among three groups.Logistic regression modle was established,and the ROC curve was used to evaluate the predict value of NLR and PLR in mycoplasma pneumoniae infection.Results:The serum NLR and PLR levels in mycoplasma pneumoniae positive group were significantly higher than those in mycoplasma pneumoniae negative group and control group(all P<0.05).Logistic regression analysis showed that NLR and PLR could predict the risk of mycoplasma pneumoniae infection(P<0.05).The AUC of NLR and PLR alone detection and combined detection were 0.709,0.683,0.717,respectively;the critical values under the NLR and PLR curves were 1.56 and 100.17,the sensitivity were 53.3%and 64.5%,the specificity were 82.5%and 67.7%.The sensitivity of the combined detection was 69.8%,and the specificity was 70.96%.Conclusion:NLR and PLR are closely related to the infection of mycoplasma pneumonia,combined detection can improve the predict efficacy of mycoplasma pneumoniae infection,and may provide new clues to the diagnosis and treatment.
作者
张燕
ZHANG Yan(Department of Pediatrics,Xi’an No.1 Hospital,Xi'an710002,China)
出处
《陕西医学杂志》
2021年第8期973-976,共4页
Shaanxi Medical Journal
基金
西安市科技计划项目[20YXYJ0006(6)]。
