摘要
目的探究补阳还五颗粒治疗气虚血瘀型急性脑梗死的疗效及其对血清神经生长因子(NGF)含量的影响。方法选择2019年2月至2020年9月佛山市中医院脑病科收治的80例气虚血瘀型急性脑梗死患者作为研究对象,根据治疗方案不同将患者分为对照组和观察组,每组各40例。对照组采用常规西药治疗,观察组在对照组的基础上加用补阳还五颗粒治疗,治疗观察14 d,比较两组治疗总有效率、治疗前后神经功能评分、血瘀积分、NGF、肿瘤坏死因子-α(TNF-α)、白介素-10(IL-10)含量变化情况。结果观察组治疗总有效率为97.50%,显著高于对照组的85.00%(P<0.05)。治疗前,两组的神经功能(NIHSS)评分、血瘀积分、血清NGF、TNF-α、IL-10水平比较,差异无统计学意义(P>0.05)。经治疗后,观察组的NIHSS评分、血瘀积分显著低于对照组,且血清TNF-α水平低于对照组,NGF、IL-10显著高于对照组(P<0.05)。结论补阳还五颗粒治疗气虚血瘀型急性脑梗死疗效确切,能有效改善患者的神经功能和血瘀程度,其机制可能与其促进血清NGF表达、减轻炎症反应有关。
Objective To explore the efficacy of Buyang Huanwu Granules on acute cerebral infarction with Qideficiency and blood-stasis syndrome and its effect on serum levels of nerve growth factor(NGF).Methods Eighty patients with acute cerebral infarction with Qi-deficiency and blood-stasis syndrome admitted to the Foshan Hospital of Traditional Chinese Medicine from February 2019 to September 2020 were selected as the research objects.The patients were divided into the control group and the observation group according to different treatment plans,with 40 cases in each group.The control group was treated with conventional Western medicine,while the observation group was supplemented with Buyang Huanwu Granules on the basis of the same treatment as the control group.After 14 days of treatment observation,the total effective rate of treatment,neurological function score before and after treatment,blood stasis score,NGF,levels of tumor necrosis factor-α(TNF-α)and interleukin-10(IL-10)were compared between the two groups.Results The total effective rate of treatment in the observation group(97.50%)was significantly higher than that in the control group 85.00%,(P<0.05).Before treatment,there were no statistically significant differences in the neurological function(NIHSS)score,blood stasis score,and serum levels of NGF,TNF-α,and IL-10 between the two groups(P>0.05).After treatment,the NIHSS score and blood stasis score of the observation group were significantly lower than those of the control group,the serum TNF-αlevel was lower than that of the control group,and NGF and IL-10 were significantly higher than those of the control group(P<0.05).Conclusion Buyang Huanwu Granules have a definitive efficacy on acute cerebral infarction with Qi-deficiency and blood-stasis syndrome,and can effectively improve the patient’s neurological function and blood stasis degree.The mechanism of action may be related to its promotion of serum NGF expression and reduction of inflammation.
作者
程南方
谭峰
梁艳桂
徐丽红
CHENG Nanfang;TAN Feng;LIANG Yangui;XU Lihong(Department of Brain Disease,the Foshan Hospital of Traditional Chinese Medicine,Guangdong,Foshan 528000,China)
出处
《中国医药科学》
2021年第13期9-12,共4页
China Medicine And Pharmacy
基金
广东省中医药局科研项目(20191313)
广东省自然科学基金项目(2016A030310239)。
关键词
急性脑梗死
气虚血瘀型
补阳还五颗粒
神经生长因子
Acute cerebral infarction
Qi-deficiency and blood-stasis syndrome
Buyang Huanwu Granules
Nerve growth factor
