摘要
目的探究清热导滞推拿法辅助消积止咳平喘汤治疗小儿功能性消化不良(FD)咳嗽积滞食积化热证对患儿血清IL-10、TNF-α及体液免疫的影响。方法选取128例小儿FD咳嗽患儿,采用随机数字表法分为对照组与观察组,各64例。2组均口服奥美拉唑钠肠溶片、潘多立酮片治疗,观察组在此基础上予消积止咳平喘汤联合清热导滞推拿法治疗,2组均治疗2周,随访3个月。观察并比较2组临床疗效,治疗前后炎症反应、体液免疫、中医证候积分,治疗期间不良反应,随访复发情况。结果治疗后,观察组总有效率(90.63%,58/64)显著高于对照组(76.56%,49/64)(P<0.05)。治疗后,2组血清IL-6、TNF-α水平降低,观察组低于对照组;2组IgA、IgM、IgG、IL-10水平升高,观察组高于对照组(P<0.05)。治疗后与治疗前比较,2组临床症状各指标(食欲不振、腹痛腹胀、恶心呕吐以及大便不调)评分均降低,观察组低于对照组(P<0.05)。治疗期间,观察组不良反应发生率与对照组比较,差异无统计学意义(P>0.05)。2组治疗结束后随访,观察组复发率(5.17%,3/58)低于对照组(22.45%,11/49)(P<0.05)。结论清热导滞推拿法辅助消积止咳平喘汤可改善小儿FD咳嗽患儿体液免疫功能,抑制机体炎症反应,减轻中医证候,安全有效,并进一步控制复发情况。
Objective To explore the effect of the heat-clearing and dyspepsia-removing massage for assisting Xiaoji Zhike Pingchuan Decoction in the treatment of the infantile functional dyspepsia(FD)cough with the syndrome of heat transformed from indigestion and dyspepsia on the serum IL-10,TNF-αand humoral immunity.Methods A total of 128 children with the infantile FD cough were selected and randomly divided into the control group and the observation group,with 64 cases in each group.Both groups were treated with omeprazole sodium enteric-coated tablets and pandolidone tablets.On this basis,the observation group was treated with Xiaoji Zhike Pingchuan Decoction combined with the heat-clearing and dyspepsia-removing massage therapy.Both groups were treated for 2 weeks and followed up for 3 months.The clinical efficacy,inflammatory response,humoral immunity,TCM syndrome score before and after treatment,the adverse reactions during treatment and the recurrence during follow-up were observed and compared between the two groups.Results After treatment,the total effective rate of the observation group(90.63%,58/64)was significantly higher than that of the control group(76.56%,49/64)(P<0.05).After treatment,the serum IL-6 and TNF-αlevels in the 2 groups were both decreased,and the observation group was lower than the control group;while the IgA,IgM,IgG,and IL-10 levels in the 2 groups were increased,and the observation group was higher than the control group(P<0.05).Compared with before treatment,the scores of the clinical symptom indexes(loss of appetite,abdominal pain,abdominal distension,nausea and vomiting,and irregular stool)in the two groups were decreased,and the observation group was lower than the control group(P<0.05).During treatment,there was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).During follow-up,the recurrence rate of the observation group(5.17%,3/58)was lower than that of the control group(22.45%,11/49)(P<0.05).Conclusion The heat-clearing an
作者
冯硕
崔德成
FENG Shuo;CUI Decheng(Department of Pediatrics,Shunyi Hospital,Beijing Hospital of Traditional Chinese Medicine,Beijing 101300,China;Department of Internal Medicine,Shunyi Hospital,Beijing Hospital of Traditional Chinese Medicine,Beijing 101300,China)
出处
《长春中医药大学学报》
2021年第4期819-823,共5页
Journal of Changchun University of Chinese Medicine
基金
北京中医医院顺义医院院级课题项目(SYYJLC-202002)。
关键词
小儿功能性消化不良
积滞食积化热证
消积止咳平喘汤
清热导滞推拿法
functional dyspepsia in children
syndrome of heat transformed from indigestion and dyspepsia
Xiaoji Zhike Pingchuan Decoction
heat-clearing and dyspepsia-removing massage therapy
