摘要
Photocleavable hydrogels are of great importance in the field of controlled drug delivery,stem cell fate regulation,surface patterning,and intelligent devices.However,the development of novel photocleavable gel systems by visible light is usually met with challenges such as the lack of efficient and tunable photocleavable groups and reactions.Herein,we reported the facile fabrication of a new type of photocleavable hydrogels by the direct gelation of 4-arm thiol-terminated polyethylene glycol with 3,6-dichloro-1,2,4,5-tetrazine via the formation of S,S-tetrazine linkages.The prepared hydrogels underwent efficient degradation upon irradiation by ultraviolet or green light,and the degradation kinetics could be significantly promoted by hydrogen peroxide.Correspondingly,the hydrogels loaded with calcium peroxide microparticles or glucose oxidase/catalase enzymes enabled the precise and efficient in vivo photocontrol of gel degradation and drug release for cancer treatment.This work offers a promising and facile strategy towards the fabrication of visible light cleavable hydrogels with tunable and ondemand drug release properties.
出处
《Research》
EI
CAS
2020年第1期1053-1063,共11页
研究（英文）
基金
This study was supported by the National Key R&D Program of China,Synthetic Biology Research(No.2019YFA0904500)
the National Natural Science Foundation of China(21725402 and 21774079)
the Shanghai Municipal Science and Technology Commission(188014580)
the Guangdong Innovative and Entrepreneurial Research Team Program(2016ZT06C322).
