摘要
目的分析APRIL、EFEMP1、TIMP2在人脑膜瘤患者血清中变化及其临床意义。方法选取本科2014年6月—2019年10月收治的脑膜瘤患者90例(脑膜瘤组),另选健康体检者90例(对照组),检测2组受试者血清APRIL、EFEMP1、TIMP2浓度;分析血清APRIL、EFEMP1、TIMP2与脑膜瘤患者临床病理特征关系,采用COX回归分析影响脑膜瘤患者预后的因素。结果脑膜瘤组患者血清APRIL、EFEMP1、TIMP2浓度均高于对照组(P<0.05)。脑膜瘤患者术后血清APRIL、EFEMP1、TIMP2浓度低于术前(P<0.05)。脑膜瘤患者不同TNM分期、WHO分级血清APRIL、EFEMP1、TIMP2浓度相比,差异有统计学意义(P<0.05)。Spearman相关性分析血清APRIL、EFEMP1、TIMP2浓度与脑膜瘤术后并发症呈正相关(r值分别为0.479、0.533、0.550,P<0.05),与NIHSS评分呈正相关(r值分别为0.424、0.356、0.459,P<0.05),与KPS评分呈负相关(r值分别为-0.453、-0.568、-0.434,P<0.05)。Cox分析血清APRIL、EFEMP1、TIMP2升高是影响脑膜瘤患者不良预后的独立危险因素。结论脑膜瘤患者血清APRIL、EFEMP1、TIMP2浓度升高与脑膜瘤TNM分期、WHO分级有关,血清APRIL、EFEMP1、TIMP2联合检测有望成为脑膜瘤诊断和预后评估的生物标志物。
Objective To analyze the changes and clinical significance of APRIL,EFEMP1,and TIMP2 in the serum of human meningioma patients.Methods We selected 90 cases of meningiomas (meningioma group) who were admitted to our department from June 2014 to October 2019,and 90 healthy people (control group) were selected for the detection of serum APRIL,EFEMP1,TIMP2 concentrations.The relationship between serum APRIL,EFEMP1,TIMP2 and clinicopathological characteristics of meningioma patients was analyzed.The factors affecting the prognosis of meningioma patients were analyzed by COX regression.Results The serum levels of APRIL,EFEMP1,and TIMP2 in patients with meningiomas were higher than those in the control group (P<0.05).The levels of serum APRIL,EFEMP1,and TIMP2 in meningioma patients were lower than those before surgery (P<0.05).There was statistical significance on the differences in serum concentrations of APRIL,EFEMP1and TIMP2 among patients with different TNM stages and WHO classification (P<0.05).Spearman correlation analysis showed that serum APRIL,EFEMP1,TIMP2 concentrations were positively correlated with postoperative complications of meningioma (r=0.479,r=0.533,r=0.550,P<0.05),and positively correlated with NIHSS score (r=0.424,r=0.356,r=0.459,P<0.05),negatively correlated with KPS score (r=-0.453,r=-0.568,r=-0.434,P<0.05).Cox analysis showed that elevated serum APRIL,EFEMP1,and TIMP2 were independent risk factors affecting the poor prognosis of meningioma patients.Conclusion The serum APRIL,EFEMP1,and TIMP2 concentrations of meningioma patients are increased,which are related to the TNM stage and WHO classification of meningiomas.The combined detection of serum APRIL,EFEMP1,and TIMP2 may be a biomarker for the diagnosis and prognosis of meningiomas.
作者
马红军
孙红卫
李永
MA Hong-jun;SUN Hong-wei;LI Yong(Neurosurgery Department,Xinzheng People's Hospital,Xinzheng,Henan 451100,China)
出处
《中国卫生检验杂志》
CAS
2021年第13期1614-1617,1624,共5页
Chinese Journal of Health Laboratory Technology
