摘要
In a recent article in Cell,Yokota et al.1 demonstrate that type V collagen,a minor component of the cardiac extracellular matrix,plays a paradoxical role in limiting scar size after myocardial infarction by altering the mechanical properties of the developing scar tissue and by regulating integrindependent activation of cardiac fibroblasts(Fig.1).
基金
support by the National Institutes of Health T32 EB009035(to S.C.),K99 HL150216(D.T.P.),and R01 HL133272,R01 HL141371,R01 HL141851,UG3 TR002588,and American Heart Association 17MERIT33610009(to J.C.W.).
