摘要
Recently,a paper published in Cell by Ho et al.describes an interesting finding how a virus can highjack the host machinery and gene sequence to synthesize its own virulence proteins to facilitate invasion,replication,and spread.The research reveals that RNA viruses like influenza A virus(IAV)can produce previously unrecognized chimeric proteins containing both viral and human genetic information,which can then affect virulence and modulate T cell responses in hosts(Fig.1).
基金
supported by National Major Scientific and Technological Special Project for“Significant New Drugs Development”(2019ZX09721001-004-004)
supported by the National Institutes of Health for Grants R01 AI138203 and R01 AI109317.
