摘要
目的:探讨单核细胞/高密度脂蛋白胆固醇比值(MHR)与冠心病血瘀证的相关性。方法:选取2018年1月至2018年7月中日友好医院收治的冠心病患者180例作为研究对象,根据冠心病血瘀证积分分为血瘀证组(n=118)和非血瘀证组(n=62),选取同期非冠心病非血瘀证患者55例作为对照组,比较3组MHR的差异。采用Logistic回归分析MHR与冠心病血瘀证的关系;通过绘制受试者工作特征曲线(ROC),评估MHR诊断冠心病血瘀证的能力。结果:血瘀证组MHR水平高于非血瘀证组和对照组(P<0.01),非血瘀证组和对照组之间MHR水平比较,差异无统计学意义(P>0.05)。Logistic回归分析表明,MHR是冠心病血瘀证的独立危险因素(HR:0.903,95%CI为0.826~0.988,P=0.026)。ROC分析表明,MHR诊断冠心病血瘀证的最佳截止值为14.15,敏感度为83.9%,特异度为68.6%[曲线下面积(AUC)0.609,95%CI为0.521~0.696,P=0.017]。结论:MHR是冠心病血瘀证的独立危险因素,提示脂质驱动的炎症反应可能是冠心病血瘀证形成病理机制之一。
Objective:To analyze the relationship between monocyte to high-density lipoprotein cholesterol ratio(MHR)with blood-stasis syndrome(BSS)in coronary heart disease(CHD).Methods:A total of 180 CHD inpatients admitted to China-Japan Friendship Hospital from January 2018 to July 2018 were selected as the research objects and were divided into a BSS group(118 cases)and a non-BSS group(62 cases)according to the score of BSS in CHD.A total of 55 participants with non-CHD and non-BSS were recruited as control group.The levels of MHR was compared among 3 groups.Logistic regression was used to analyze the relationship between MHR and BSS score.And receiver operating characteristic(ROC)curve was drawn to evaluate the ability of MHR to diagnose BSS of coronary CHD.Results:The levels of MHR in the BSS group was significantly higher than non-BSS group and control group(P<0.01),but there were no statistical difference between non-BSS group and control group(P>0.05).Logistic regression analysis showed that MHR was an independent risk factor for BSS in CHD[HR:0.903,95%CI(0.826 to 0.988),P=0.026].ROC curve analysis demonstrated that the optimal cut-off value of MHR to diagnose BSS in CHD were 14.15,sensitivity of 83.9%,specificity of 68.6%[area under the curve(AUC)0.609,95%CI(0.521 to 0.696);P=0.017].Conclusion:MHR is an independent risk factor for BSS in CHD,which suggests that lipid-driven inflammation may be one of the pathological mechanisms of BSS in CHD.
作者
彭菊琴
任钧国
张艺楠
李春岩
PENG Juqin;REN Junguo;ZHANG Yinan;LI Chunyan(Institute of Basic Medical Sciences,China Academy of Chinese Medical Sciences Xiyuan Hospital/Beijing Key Laboratory of Pharmacology of Chinese Materia Medica,Beijing 100091,China;Beijing University of Chinese Medicine,Beijing 100029,China;China-Japan Friendship Hospital,Beijing 100029,China)
出处
《世界中医药》
CAS
2021年第14期2157-2162,共6页
World Chinese Medicine
基金
国家重点研发计划项目(2017YFC1700100)
北京市科技计划项目(Z171100001717024)。
关键词
冠心病
血瘀证
单核细胞/高密度脂蛋白胆固醇比值
炎症
脂质代谢紊乱
理化指标
诊断
相关性
Coronary heart disease
Blood-stasis syndrome
Monocyte to high-density lipoprotein cholesterol ratio
Inflammation
Lipid metabolism disorder
Physiochemical index
Diagnosis
Relationship
