摘要
目的观察宁夏汉族老年人稳定期慢性阻塞性肺疾病(COPD)与1,4,5-三磷酸肌醇3激酶C(ITPKC)、磷脂酶C样1蛋白(PLCL1)单核苷酸多态性(SNP)的相关性.方法采用病例对照研究方法,选取老年COPD稳定期汉族患者250例,分为COPD相关肺动脉高压(PH)组103例、COPD非PH组147例,同期选取老年汉族健康对照组127例作为对照组,检测ITPKC基因和PLCL1基因纳入位点的基因型,比较各组等位基因及基因型频率间的差异.结果rs2288450等位基因(χ^(2)=6.09,P=0.048)及基因型频率(χ^(2)=5.18,P=0.020)和rs9789480位点等位基因(χ^(2)=30.14,P<0.001)及基因型频率(χ^(2)=32.89,P<0.001)的分布在COPD组与健康对照组间差异有统计学意义,rs2290692、rs17713068位点等位基因及基因型频率分布在健康对照组与COPD组间的差异无统计学意义(均P>0.05);PLCL1基因rs9789480位点等位基因(χ^(2)=94.50,P<0.001)及基因型(χ^(2)=72.76,P<0.001)频率分布在COPD非PH组与COPD相关PH组间差异有统计学意义.而rs2290692、rs17713068、rs2288450位点等位基因及基因型频率分布在COPD相关PH组与COPD非PH组患者之间的差异均无统计学意义(均P>0.05).结论ITPKC基因rs2288450位点携带CA、AA基因型及A等位基因可能是老年人罹患COPD的保护性因素,可降低老年人COPD的发病率.PLCL1基因rs9789480位点携带CA、AA基因型及A等位基因可能是老年人罹患COPD及COPD-PH的保护性因素,可降低老年人COPD及COPD-PH的发病率.
Objective To investigate the correlations of stable chrome obstructive pulmonary disease(COPD)with inositol 1,4,5-trisphosphate 3-kinase C(ITPKC)and phospholipase C-like 1 protein(PLCLl)single nucleotide polymorphisms(SNPs)in the Han elderly population in Ningxia.Methods A case-control study was conducted.A total of 250 elderly patients with stable COPD were enrolled and divided into the COPD-related pulmonary hypertension(PH)group(n=103)and the COPD non-PH group(n=147).During the same period,127 healthy elderly Han subjects were included as the control group.The ITPKC gene SNPs and the PLCL1 gene SNP were detected,and differences in alleles and genotype frequencies were compared between the groups.Results The allele and genotype frequency distributions of rs2288450 and rs978948Q showed statistical differences between the COPD group and the control group(χ^(2)=6.09,5.18,30.14 and 32.89=0.048,0.020,<0.001,<0.001).There was no difference in the allele and genotype frequency distributions of the ITPKC gene SNPs rs2290692 and rsl7713068 between the control group and the COPD group(all P>0.05).The allele and genotype frequency distributions of rs9789480 showed differences between the COPD non-PH group and the COPD-PH group(χ^(2)=94.50 and 72.76,both P<0.001).There was no significant difference in the allele and genotype frequency distributions of rs2290692,rsl7713068,rs2288450 between the COPD-PH group and the COPD non-PH group(all P>0.05).Conclusions The ITPKC gene SNP rs2288450 CA and AA genotypes and A allele can reduce the incidence of COPD and may be a protective factor for COPD in the elderly.The PLCL1 gene SNP rs9789480 CA and AA genotypes and A allele can reduce the incidence of COPD and COPD-PH and may be a protective factor for COPD and COPD-PH in the elderly.
作者
谢欣芸
王曦
耑冰
苑群
李萍
谢俊
杨朝
Xie Xinyun;Wang Xi;Zhuan Bing;Yuan Qun;Li Ping;Xie Jun;Yang Zhao(Department of Respiratory Medicine,the First Affiliated Hospital of Medical College of Northwest Minzu University,People's Hospital of Ningxia Hui Autonomous Region,Yinchuan 750011,China;Department of Respiratory Medicine,the Affiliated Suzhou Science&Technology Town Hospital of Nanjing Medical University,Suzhou 215153,China)
出处
《中华老年医学杂志》
CAS
CSCD
北大核心
2021年第7期853-858,共6页
Chinese Journal of Geriatrics
基金
国家自然科学基金(81560014)
宁夏回族自治区重点研发计划一般项目(2018BEG03052)
2019年苏州市临床重点病种诊疗技术专项(LCZX201931)
2019年苏州高新区医疗卫生科技计划(2019Z002)。
关键词
肺疾病
慢性阻塞性
高血压
肺性
多态性
单核苷酸
Pulmonary disease,chronic obstructive
Hypertension pulmonary
Polymorphism,single nucleotide
