摘要
结直肠癌是最常见的恶性肿瘤之一。髓过氧化物酶(MPO)作为中性粒细胞溶酶体中的一种氧化酶,在激活致癌基因中间体和增强外源性致癌方面起着重要作用,其通过产生次氯酸、活性氧等氧化剂激发体内氧化应激反应,诱导DNA损伤、突变、错配修复等基因不稳定因素发生,从而导致了结直肠癌的发生、发展。MPO单核苷酸基因多态性(SNP)与癌症的遗传易感性有关,MPO rs2333227-463G>A可降低结直肠癌风险。针对MPO、MPO-463G>A的研究,将为结直肠癌的早期发现、预防、病情评估及靶向治疗方案的研发提供新的思路和有力证据。
Colorectal cancer is one of the most common malignant tumors.Myeloperoxidase(MPO),as an oxidase in neutrophils lysosomes,plays an important role in activating carcinogenic gene intermediates and enhancing exogenous carcinogenesis.It can stimulate oxidative stress reaction in vivo by producing hypochlorite,reactive oxygen species and other oxidants,and induce gene instability factors such as DNA damage,mutation,mismatch repair and so on,which leads to the occurrence and development of colorectal cancer.MPO single nucleotide polymorphism(SNP)is related to the genetic susceptibility of cancer.Mpors 2333227-463G>A can reduce the risk of colorectal cancer.Therefore,the research on MPO,MPO-463G>A will provide new ideas and strong evidence for early detection,prevention,disease assessment and targeted treatment of colorectal cancer.
作者
梁海清
李一然
张淑燕
曹丽群
Liang Haiqing;Li Yiran;Zhang Shuyan;Cao Liqun(Second Department of Internal Medicine,Dezhou People′s Hospital,Dezhou 253014,China)
出处
《中国医师杂志》
CAS
2021年第6期958-960,F0003,共4页
Journal of Chinese Physician
关键词
结直肠肿瘤
髓过氧化物酶
多态性
单核苷酸
Colorectal neoplasms
Myeloperoxidase
Polymorphism,single nucleotide
