摘要
细胞焦亡是近年来证实的一种新的程序性细胞死亡方式,由消化道皮肤素介导,表现为细胞不断胀大直至细胞膜破裂,导致细胞内容物的释放进而激活强烈的炎症反应,导致细胞程序性坏死。细胞焦亡的主要通路包含依赖半胱天冬氨酸蛋白酶(caspase)-1的经典通路和依赖caspase-4、5、11的非经典通路。细胞焦亡在原发性肝癌的癌前病变以及发展过程中起重要作用,归纳总结了细胞焦亡的分子机制及其在原发性肝癌治疗中的研究进展,以期为原发性肝癌的诊断、治疗以及新药研发提供新的依据。
Pyroptosis is a new type of programmed cell death that has been confirmed in recent years.It is mediated by digestive tract dermatans,which manifests itself as the continuous expansion of cells until the cell membrane ruptures,leading to the release of cell contents and activating a strong inflammatory response.Lead to programmed cell necrosis.The main pathways of pyroptosis include the classical pathways dependent on caspase-1 and the non-classical pathways dependent on caspase-4,5,and 11.Cell pyroptosis plays an important role in the precancerous lesions and development of primary liver cancer.The molecular mechanism of pyroptosis and its research progress in the treatment of primary liver cancer are summarized,with a view to the diagnosis of primary liver cancer,treatment and new drug development to provide new basis.
作者
黄鑫悦
晁旭
黄峰
HUANG Xinyue;CHAO Xu;HUANG Feng(Shaanxi University of Traditional Chinese Medicine,Xianyang 712000,China;The Second Affiliated Hospital of Shaanxi University of Traditional Chinese Medicine,Xianyang 712000,China)
出处
《药物评价研究》
CAS
2021年第7期1535-1540,共6页
Drug Evaluation Research
基金
国家自然科学基金资助项目(81774132)。
