摘要
目的:研究生髓健骨胶囊对酒精性骨质疏松大鼠血清钙(Ca)、磷(P)、碱性磷酸酶(ALP)及骨钙素(BGP)生化指标的影响。方法:120只SD大鼠,随机分成四组:模型组、空白对照组、西药对照组、中药干预组,每组各30只,用白酒灌胃造模,同时给予生髓健骨胶囊和0.9%NaCl注射液、碳酸钙片与阿法D3和0.9%NaCl注射液分别配制成混悬液灌胃。干预8、12、16周后取材,用全自动生化分析仪测定血清钙、磷、碱性磷酸酶的含量,并用RIA法测定骨钙素含量。结果:模型组与空白对照组相比,血清Ca、P、ALP及BGP明显降低,差异有统计学意义(P<0.01)。西药对照组、中药干预组血清Ca、P、ALP及BGP高于模型组,差异有统计学意义(P<0.01)。中药干预组效果优于西药对照组,差异有统计学意义(P<0.05)。结论:生髓健骨胶囊具有提高血清钙、磷、碱性磷酸酶及骨钙素含量,起到防治酒精性骨质疏松的作用。
Objective:To study the efficacy of Shengsui Jiangu capsule on serum calcium(Ca), phosphorus(P), alkaline phosphatase(ALP) and Osteocalcin(BGP) biochemical indexes in rats with alcoholic osteoporosis.Methods: 120 SD rats were randomly divided into four groups: model group, blank control group, western medicine control group and traditional Chinese medicine intervention group, with 30 rats in each group.The model was established by intragastric administration of liquor.The blank control group was established by intragastric administration of 0.9% NaCl liquor.The western medicine control group was established by intragastric administration of alcium carbonate tablets and Alfa D3 and 0.9% NaCl injection liquor.The traditional Chinese medicine intervention group was established by intragastric administration of Shengsui Jiangu capsule and 0.9% NaCl injection liquor.After 8, 12 and 16 weeks of intervention, serum calcium, phosphorus and alkaline phosphatase were measured by automatic biochemical analyzer, and osteocalcin was measured by RIA.Results: Compared with the blank control group, serum Ca, P, ALP and BGP in the model group were significantly decreased(P<0.01).Serum Ca, P, ALP and BGP in western medicine control group and Chinese medicine intervention group were higher than those in model group(P<0.01).The efficacy of traditional Chinese medicine intervention group was better than that of western medicine control group(P<0.05), with statistical significance.Conclusion: Shengsui Jiangu capsule can improve the content of serum calcium, phosphorus, alkaline phosphatase and osteocalcin, and prevent and treat alcoholic osteoporosis.
作者
任树军
于长江
梁彦林
杜海月
李远峰
徐西林
REN Shujun;YU Changjiang;LIANG Yanlin;DU Haiyue;LI Yuanfeng;XU Xilin(The First Affiliated Hospital of Heilongjiang University of Chinese Medicine,Harbin 150040,China;Graduate School of Heilongjiang University of Chinese Medicine,Harbin 150040,China;Ningxia Hospital and Research Institute of Chinese Medicine,Yinchuan 750021,China;The Second Affiliated Hospital of Heilongjiang University of Chinese medicine,Harbin 150001,China)
出处
《中国中医骨伤科杂志》
CAS
2021年第7期21-24,共4页
Chinese Journal of Traditional Medical Traumatology & Orthopedics
基金
黑龙江省自然科学基金项目(LH2020H086)
黑龙江省中医药管理局项目(ZHY10-W22)。
关键词
生髓健骨胶囊
酒精性骨质疏松
血清生化指标
Shengsui Jiangu capsule
alcoholic osteoporosis
serum biochemical indexes
