摘要
目的了解儿科病房呼吸道标本中耐甲氧西林金黄色葡萄球菌(MRSA)检出和耐药情况,为临床合理用药提供依据.方法回顾性分析2019年1月至2020年12月儿科病房患者呼吸道标本分离到的422株金黄色葡萄球菌,采用WHONET 5.6软件统计其分离情况和MRSA的检出率,并对MRSA的耐药情况进行分析。结果422株金黄色葡萄球菌,2019年检出237株,MRSA检出率28.57%;2020年检出149株,MRSA检出率21.48%。金黄色葡萄球菌对对万古霉素、替考拉宁、利奈唑胺、呋喃妥因均敏感,对青霉素耐药率>90%,对其它药物有不同程度的耐药性。MRSA和甲氧西林敏感金黄色葡萄球菌(MSSA)对苯唑西林、阿莫西林/克拉维酸以及红霉素耐药率差异有统计学意义(P<0.05)结论通过对儿科病房MRSA的检测和耐药分析,能进一步对MRSA进行有效防控,根据药敏结果规范用药,对临床治疗具有重要意义。
Objective To investigate the distribution and antibiotic resistance of methicillin-resistant Staphylococcu saureus(MRSA),to guide clinical drug selection.Methods January 2019 to December 2020,we retrospectively collected S.saureus stains from respiratory tract samples of patients in paediatric ward.Statistics data showed the rate of S.saureus and MRSA by WHONET 5.6 and the drug resistance of MRSA to 15 antibiotics were also analyzed.Results A total of 422 S.aureus strains were isolated from 2019 to 2020 in the pediatric ward of our hospital.237 S.aureus strains were collected with a MRSA detection rate of 28.57%in 2019,149 S.aureus strains with 21.48%MRSA rate in 2020.All of S.aureus strains were sensitive to vancomycin,teicoplanin,linezolid,and nitrofurantoin.The resistance rate to penicillin was more than 90%,S.aureus strains had different degrees resistence for other antibiotics.The resistance rates of oxacillin,amoxicillin/clavulanic acid,erythromycin were statistically different between MRSA and methicillin-sensitive S.aureus(P<0.05).Conclusion On the basis of the study,showed the infection rate and resistance of MRSA in the pediatric ward of our hospital,which is effective in controlling nosocomial infection of MRSA.And regulate the medication according to the results of drug sensitivity,which has positive clinical significance.
出处
《浙江临床医学》
2021年第7期1030-1031,共2页
Zhejiang Clinical Medical Journal
关键词
儿科
金黄色葡萄球菌
耐甲氧西林金黄色葡萄球菌
耐药分析
Paediatric ward
Staphylococcus aureus
Methicillin-resistant
Staphylococcu saureus
Resistance analysis
