摘要
法尼醇X受体(Farnesoid X receptor,FXR),又称胆汁酸受体,因与代谢调节密切相关,FXR激动剂目前成为代谢性疾病治疗的药物研发热点。FXR天然激动剂来源广泛且大部分具有无或低毒副作用的特点,主要分为动物源性激动剂、植物源性激动剂和微生物源性激动剂三大类。动物源性激动剂包括鹅脱氧胆酸、胆酸、脱氧胆酸、石胆酸和熊去氧胆酸等内源性胆汁酸,以及雄甾酮;植物源性激动剂包括植物和植物提取物,如泽泻提取物、咖啡醇、香豆雌酚、葡萄内脂和薯蓣皂苷;微生物源性激动剂包括细格菌素。本文就FXR天然激动剂的研究进展进行综述。
Due to the significant association of Farnesoid X receptor(FXR)with metabolic regulation,FXR agonists have become a hotspot for drug research and development in the treatment of metabolic diseases.FXR natural agonists have a wide range of sources and most of them have the characteristics of no or low side effects.They are mainly divided into three categories:animal-derived agonists,plant-derived agonists and microbial-derived agonists.Animal-derived agonists include endogenous bile acids such as chenodeoxycholic acid,cholic acid,deoxycholic acid,lithocholic acid and ursodeoxycholic acid as well as androsterone;plant-derived agonists include plants and plant extracts,such as Alisma extract,caffeol,couestrol,grape lactone and dioscin;microbial-derived agonists include serotonin.This article reviews the research progress of FXR natural agonists.
作者
明文华
栾志琳
张晓燕
管又飞
MING Wenhua;LUAN Zhilin;ZHANG Xiaoyan;GUAN Youfei(Advanced Institute for Medical Sciences,Dalian Medical University,Dalian 116044,China)
出处
《大连医科大学学报》
CAS
2021年第3期244-250,共7页
Journal of Dalian Medical University
基金
国家自然科学基金项目(91639201,81722010,81601174)。
