摘要
低代谢休眠是指机体进入深度睡眠状态(即休眠),机体代谢率显著降低。目前对于触发和维持这种低体温低代谢状态的神经和体液机制仍知之甚少。研究表明,诱导和维持低代谢休眠需要激活中枢A1腺苷受体(A1AR),A1AR在低代谢休眠的诱导中起着独特而重要的作用,有望成为未来人工诱导冬眠的突破口。综述了近年来A1AR在低代谢休眠诱导中的作用研究进展,论述了A1AR在自然冬眠中的作用,并从A1AR抑制棕色脂肪组织活性,抑制延髓中缝苍白核神经元,抑制心血管与脑电活动及一磷酸腺苷的作用等方面探讨了A1AR在诱导低温低代谢休眠中的可能机制,为开展长期空间飞行医学保障相关研究提供参考。
Hypometabolic dormancy refers to the state of the body into a deep sleep(hibernation)and the significant reduction of the body metabolic rate.Little is known about the neural and humoral mechanisms that trigger and maintain this state of hypothermia and hypometabolism.Many studies have shown that the activation of central A1 adenosine receptor(A1 AR)is necessary to induce and maintain hypometabolic hibernation.A1 AR plays a unique and important role in the induction of hypometabolic hibernation,and is expected to become a breakthrough in the artificial induction of hibernation in the future.The research progress of the role of A1 AR in the induction of hypometabolic hibernation in recent years was reviewed and the role of A1 AR in natural hibernation was discussed.Then the possible mechanism of A1 AR in inducing hypothermia and hypometabolism hibernation was discussed from the following aspects:inhibition of brown adipose tissue activity,inhibition of neurons in raphe pallidus nucleus,inhibition of cardiovascular and EEG activities,and the effect of adenosine monophosphate.This review may help to explore the possible mechanism of A1 AR in inducing low temperature and low metabolism hibernation and to provide reference for the researches of medical support during long-term spaceflight.
作者
刘书林
姚永杰
刘秋红
巴剑波
Liu Shulin;Yao Yongjie;Liu Qiuhong;Ba Jianbo(不详;Human Factors of Navigation and Effect Prevention of High/Technology Weapons Device,Naval Medical Center,Naval Military Medical University,Shanghai 200433,China)
出处
《航天医学与医学工程》
CAS
CSCD
北大核心
2021年第3期260-265,共6页
Space Medicine & Medical Engineering
基金
载人航天领域预先研究项目(020103)。
关键词
A1腺苷受体
低温
低代谢
休眠
A1 adenosine receptor
hypothermia
hypometabolism
hibernation
