摘要
五味子是传统的保肝药物,其不仅可降低氨基转移酶水平,还具有抗氧化、抗炎和抑制细胞凋亡等多种药理作用,被广泛应用于各种类型的肝损伤,其分子机制主要与Nrf2信号通路、孕烷X受体、p53/p21信号通路、核因子κB信号通路及丝裂原活化蛋白激酶信号通路有关。本文通过查阅文献,对五味子保肝作用的分子机制进行总结,以期为五味子的合理应用提供参考。
Schisandra chinensis is a traditional hepatoprotective drug,which can not only reduces aminotransferase levels,but also has various pharmacological effects such as antioxidant,anti-inflammatory and apoptosis inhibition,and is widely used in treatment of various types of liver injury,its molecular mechanisms are mainly related to the Nrf2 signaling pathway,pregnane X receptor,p53/p21 signaling pathway,nuclear factor κB signaling pathway and mitogen-activated protein kinase signaling pathway. This paper has reviewed related literature to summarize the molecular mechanisms of hepatoprotective effects of schisandra chinensis,so as to provide references for the rational application of schisandra chinensis.
作者
付冉
李日
王小楠
崔艳军
范理菊
董占军
FU Ran;LI Ri;WANG Xiaonan;CUI Yanjun;FAN Liju;DONG Zhanjun(Graduate School,Hebei Medical University,Hebei Shijiazhuang 050017,China;Dept.of Pharmacy,Hebei General Hospital,Hebei Shijiazhuang 050051,China;Graduate School,North China University of Science and Technology,Hebei Tangshan 063000,China)
出处
《中国医院用药评价与分析》
2021年第6期761-763,768,共4页
Evaluation and Analysis of Drug-use in Hospitals of China
基金
河北省2016年度医学科学研究重点课题计划(No.20160064)。
关键词
五味子
肝损伤
作用机制
研究进展
Schisandra chinensis
Liver injury
Mechanism of action
Research progress
