摘要
目的:系统评价妇科千金片(胶囊)联合克林霉素治疗盆腔炎的临床疗效与安全性。方法:计算机检索中国知网、万方数据库、维普数据库和Pub Med等数据库中从建库至2020年11月发表的中英文文献,筛选妇科千金片(胶囊)联合克林霉素治疗盆腔炎的随机对照试验文献[研究组患者使用妇科千金片(胶囊)与克林霉素联合治疗,对照组患者单独使用克林霉素治疗],根据纳入与排除标准纳入研究文献,提取资料并进行发表风险偏倚评价后,采用Rev Man 5.3软件对纳入的文献进行荟萃分析(Meta分析)。结果:纳入12篇文献,共1 426例患者,其中研究组患者715例,对照组患者711例;7篇文献提及不良反应。Meta分析结果显示,研究组患者的有效率(OR=3.31,95%CI=2.38~4.59,Z=7.15,P <0.000 01)、不良反应发生率(OR=0.43,95%CI=0.25~0.74,Z=3.04,P=0.002)、下腹疼痛改善情况(MD=-0.73,95%CI=-0.84~-0.62,Z=12.80,P <0.000 01)和白带量改善情况(MD=-0.80,95%CI=-0.98~-0.61,Z=8.38,P <0.000 01)均明显优于对照组,上述差异均有统计学意义。结论:妇科千金片联合克林霉素治疗盆腔炎具有较好的有效率和较高的安全性。
OBJECTIVE: To systematically review the clinical efficacy and safety of Fuke Qianjin tablets( capsule)combined with clindamycin in the treatment of pelvic inflammatory. METHODS: Randomized controlled trials in Chinese and English on Fuke Qianjin tablets( capsule) combined with clindamycin in the treatment of pelvic inflammatory[the research group was given Fuke Qianjin tablets( capsule) combined with clindamycin,while the control group was given clindamycin alone]were retrieved from CNKI,Wanfang database VIP database and Pub Med from basebuilding to Nov. 2020,after the literature screening according to the inclusion and exclusion criteria,the data was extracted and evaluated or publication risk bias,and the Rev Man 5. 3 was adopted to conduct a Meta-analysis on the included literature. RESULTS: Totally 12 studies were involved,including 1 426 patients,of which 715 patients were in the research group and 711 patients were in the control group;7 studies had mentioned adverse drug reactions. Results of Meta-analysis indicated that the effective rate( OR = 3. 31,95% CI = 2. 38-4. 59,Z = 7. 15,P < 0. 000 01),incidence of adverse drug reactions( OR = 0. 43,95% CI = 0. 25-0. 74,Z = 3. 04,P = 0. 002),improvement of hypogastralgia( MD=-0. 73,95% CI =-0. 84--0. 62,Z = 12. 80,P < 0. 000 01) and improvement of leucorrhea amount( MD =-0. 80,95% CI =-0. 98--0. 61,Z = 8. 38,P < 0. 000 01) of research group were significantly better than those of the control group,with statistically significant differences. CONCLUSIONS: The combination of Fuke Qianjin tablets( capsule) and clindamycin has good effectiveness and high safety in the treatment of pelvic inflammatory.
作者
王卓媛
白换换
苟小军
赵艳
吴嫣
WANG Zhuoyuan;BAI Huanhuan;GOU Xiaojun;ZHAO Yan;WU Yan(School of Pharmacy,Shaanxi University of Traditional Chinese Medicine,Shaanxi Xianyang 712046,China;Dept.of Obstetrics and Gynecology,Central Laboratory Baoshan Hospital of Integrated Traditional Chinese and Western Medicine,Shanghai 201999,China)
出处
《中国医院用药评价与分析》
2021年第6期718-721,729,共5页
Evaluation and Analysis of Drug-use in Hospitals of China
基金
上海市进一步加快中医药事业发展三年行动计划(2018年—2020年)项目[No.ZY(2018-2020)-ZYBZ-22]。
关键词
妇科千金片
克林霉素
盆腔炎
META分析
Fuke Qianjin tablets
Clindamycin
Pelvic inflammatory
Meta-analysis
