摘要
目的分析糖类抗原153(CA153)、糖类抗原199(CA199)联合甲胎蛋白(AFP)检测在卵巢癌病情进展、化疗近期疗效评估中的应用价值。方法选取2016年11月至2018年11月本院收治的108例卵巢癌患者临床资料为研究组。另选取同期在本院接受健康体检的正常妇女100例作为对照组。对比不同研究对象CA153、CA199、AFP水平差异,分析CA153、CA199、AFP在卵巢癌患者中的变化,采用非条件单因素和多因素Logistic回归模型分析影响卵巢癌患者化疗疗效的相关因素,采用ROC曲线分析CA153、CA199联合AFP检测在卵巢癌化疗近期疗效评估中的应用价值。结果研究组治疗前CA153、CA199、AFP水平较对照组高,差异有统计学意义(P<0.05)。研究组治疗后CA153、CA199、AFP水平较治疗前降低,差异有统计学意义(P<0.05),且与对照组比较差异无统计学意义(P>0.05)。FIGO分期:Ⅲ+Ⅳ期、分化程度:低分化、存在淋巴转移者CA153、CA199、AFP水平高于FIGO分期:Ⅰ+Ⅱ期、分化程度:中高分化及无淋巴转移者,差异具有统计学意义(P<0.05)。108例患者治疗有效率为78.70%,无效率为21.30%。FIGO分期、CA153、CA199、AFP水平为影响卵巢患者化疗近期疗效的独立危险因素(P<0.05)。CA153、CA199、AFP三者联合检测AUC(0.71)最大。结论 CA153、CA199、AFP水平在卵巢癌患者中显著上升,联合监测三者水平可有效评估卵巢癌患者病情发展、化疗近期疗效。
Objective To analyze the application value of carbohydrate antigen 153(CA153),carbohydrate antigen 199(CA199)combined with alpha fetoprotei(AFP)detection in the evaluation of the disease progress of ovarian cancer and the short-term efficacy of chemotherapy. Methods The clinical data of108 patients with ovarian cancer admitted to this hospital from November 2016 to November 2018 were retrospectively analyzed and selected as the study group. In addition,100 women who received physical examination in this hospital during the same period were selected as the control group. The levels of CA153,CA199,and AFP in different subjects were compared,and the changes of CA153,CA199,and AFP in patients with ovarian cancer were analyzed. Unconditional univariate and multivariate logistic regression models were used to analyze the related factors that affect the efficacy of chemotherapy in patients with ovarian cancer. The ROC curve was used to analyze the application value of CA153 and CA199 combined with AFP in the evaluation of the short-term efficacy of chemotherapy for ovarian cancer. Results The levels of CA153,CA199,and AFP in the study group before treatment were higher than those in the control group,and the differences were statistically significant(P<0.05). After treatment,the levels of CA153,CA199,and AFP in the study group were lower than those before treatment,the differences were statistically significant(P<0.05),and compared with those in the control group,the differences were not statistically significant(P>0.05). FIGO staging:Ⅲ + Ⅳ,degree of differentiation:poorly differentiated,with lymphatic metastasis,CA153,CA199,AFP levels are higher than FIGO staging:Ⅰ+Ⅱ,degree of differentiation:moderately differentiated and no lymphatic metastasis,the difference is statistically significant(P<0.05). The effective rate of treatment in 108 patients was 78.70%,and the ineffective rate was 21.30%. FIGO staging,CA153,CA199,and AFP levels were independent risk factors that affect the short-term efficacy of chemotherapy
作者
张佟
王文莉
叶红
ZHANG Tong;WANG Wenli;YE Hong(Gynecological Minimally Invasive Center,Beijing Obstetrics and Gynecology Hospital,Capital Medical University,Beijing,China,100006)
出处
《分子诊断与治疗杂志》
2021年第6期956-960,共5页
Journal of Molecular Diagnostics and Therapy
